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The effect of multiple administrations of sevoflurane was evaluated by several measures of toxicity. Cynomolgus monkeys assigned to a control group and three treatment groups were anesthetized with sevoflurane at 1.0, 1.6, and 2.0 times the minimum alveolar anesthetic concentration (MAC) for 3 h/day, 3 days/wk for 8 wk. Reductions in total erythrocyte and leukocyte counts and increases in serum enzymes were the only changes noted. The increases in the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactic dehydrogenase (LDH), and creatinine kinase (CK), occurred at Week 1 at all three concentrations of sevoflurane. These increases were dose-related, and returned to baseline by Week 2 for 1.0 MAC. All serum enzyme concentrations had returned to baseline by the end of the study. There were no gross pathologic, histopathologic, or ultrastructural differences found in any of the four groups of monkeys. At 2.0 MAC, three deaths occurred. The multiple administrations of 1.0 and 1.6 MAC sevoflurane anesthesia were well tolerated by the monkeys. The techniques of this study did not detect adverse effects from the above enzyme changes.

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As we strive to showcase Sandia's diverse missions, career opportunities, encourage collaboration, and above all, highlight our dedication to national service and world-class engineering and service solutions, we must have facilities and tools to support and foster that vision. Sandia sustains an aging infrastructure at multiple sites consisting of more than 1,000 structures occupying more than 7 million square feet. The average age of all our facilities is 38 years, many dating to the late 1940s. The purpose of this Integrated Facilities & Infrastructure Plan is to advance the management, stewardship, improvement, and acquisition of facilities and infrastructure, as well as ensure limited resources are appropriately applied. In this document, you will read about the overarching facilities and infrastructure strategy, the long-range site development framework, and the facilities and infrastructure investment plan. These documents outline the priorities, goals, and principles by which we manage our current site and make investment decisions. It is an effective tool used to define and share our long-range vision for the laboratories, and to budget and prioritize immediate and short-term capital actions. I believe the strategic execution of a thoughtful and comprehensive facilities and infrastructure plan for Sandia is one of the defining issues of our time. Stewardship of our unique facilities must enhance our capabilities and create an environment that aligns with our mission needs and attracts, motivates, and retains our extremely talented people. If we are to continue to push the frontiers of science and technology, let us commit to a facilities and infrastructure renewal that supports our long-term direction and strategy.

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