Herein we report the first redox-neutral visible-light photocatalytic intermolecular dipolar cycloaddition for the diastereoselective synthesis of isoxazolidines. We have found that vinyl nitrones with a diverse substitution pattern undergo visiblelight-promoted cycloadditions with conjugated carbonyls in the presence of catalytic amounts of Ru(bpy) 3 Cl 2 , with the reaction proceeding with high yields and good selectivities. A redoxneutral pathway is proposed as the primary photoredox mechanism for this transformation.
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