Use of cardiotomy suction resulted in significant increases in thrombin, neutrophil, and platelet activation, as well as the release of neuron-specific enolase, after cardiopulmonary bypass. Limiting increases in these markers would be best accomplished by eliminating cardiotomy suction and routinely using heparin-bonded circuits whenever possible.

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We hypothesized that measurement of a specific product from reaction ofNN'-dimethylthiourea (Me2TU) and H202 would provide a good indication of the H202 scavenging and protection seen after addition of Me2TU to biological systems. We found that addition of H202

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