Sleep disorders are common complaints in patients with neurodegenerative diseases such as spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD)--SCA3/MJD. We evaluated the frequency of sleep disorders in SCA3/MJD patients against controls matched by age and gender, and correlated data with demographic and clinical variables. The main sleep disorders evaluated were rapid eye movement (REM) sleep behavior disorder (RBD), restless leg syndrome (RLS), and excessive daytime sleepiness (EDS). We recruited 40 patients with clinical and molecular-proven SCA3/MJD and 38 controls. We used the following clinical scales to evaluate our primary outcome measures: RBD Screening Questionnaire, International RLS Rating Scale, and Epworth Sleepiness Scale. To evaluate ataxia-related motor and non-motor features, we applied the International Cooperative Ataxia Rating Scale, the Scale for the Assessment and Rating of Ataxia, and the Unified Parkinson's Disease Rating Scale part III. Psychiatric manifestations were tested with the Hamilton Anxiety Scale, and Beck Depression Inventory. The frequency of RBD and RLS were significantly higher in the SCA3/MJD group than in the control group (p < 0.001). There was no difference between both groups with regard to EDS. The accuracy of RDBSQ to discriminate between cases and controls was considered the best area under the ROC curve (0.86). Within-SCA3/MJD group analysis showed that anxiety and depression were significantly correlated with RDB, but not with RLS. Additionally, depression was considered the best predictive clinical feature for RDB and EDS.

-Objective: To analyze the demographic features of the population sample, the time of headache complaint until first consultation and the diagnosis of primary and secondary headaches. Method: 3 3 2 8 patients were analyzed re t rospectively and divided according to gender, age, race, school instruction, onset of headache until first consultation and diagnosis (ICHD-II, 2004). Results: Sex ratio (Female/Male) was 4:1, and the mean age was 40.7±15 years, without statistical diff e rences between sexes. Appro x i m a t e l y 65% of the patients were white and 55% had less than eight years of school instruction. Headache complaint until first consultation ranged from 1 to 5 years in 32.99% patients. The most prevalent diagnosis w e re migraine (37.98%), tension-type headache-TTH (22.65%) and cluster headache (2. 73%). C o n c l u s i o n :T h e re are few data on epidemiological features of headache clinic populations, mainly in developing countries. According to the literature, migraine was more frequent than TTH. It is noteworthy the low school instruction of this sample and time patient spent to seek for specialized attention. Hypnic headache syndrome was seen with an unusual frequency.KEY WORDS: headache, clinic-based study, epidemiology.Epidemiologia das cefaléias primárias e secundárias em um serviço terciário brasileiro. RESUMO -Objetivo:Analisar os aspectos demográficos da população em estudo, o tempo decorrido desde o início da queixa de cefaléia até a busca pelo serviço, assim como o diagnóstico das cefaléias primárias e secundárias. Método: 3328 pacientes foram analisados re t rospectivamente de acordo com sexo, idade, raça, escolaridade, tempo decorrido entre o início da cefaléia e a busca ao médico e diagnóstico (ICHD-II, 2 0 0 4 ) . Resultados: A razão Mulher/Homem foi 4:1, ambos com média de idade 40,7±15anos, não havendo diferença significativa entre os sexos. Aproximadamente 65% dos pacientes eram brancos e 55% tinha menos de 8 anos de escolaridade. A duração da queixa de cefaléia até a primeira consulta foi de 1 a 5 anos em 32,99% dos pacientes. Os diagnósticos mais prevalentes foram: migrânea (37,98%), cefaléia do tipo tensional-CTT (22,65%) e cefaléia em salvas (2,73%). Conclusão: Existem poucos dados epidemiológicos de pacientes atendidos em serviços terciários, principalmente em países subdesenvolvidos. De acordo com a literatura, a migrânea foi mais prevalente que a CTT. Também é relevante observar a baixa escolaridade da população, assim como o grande tempo de espera até a primeira consulta. Um número incomum de pacientes com síndrome de cefaléia hípnica foi observado na amostra.

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OBJECTIVE: To determine the clinical correlates of the restless legs syndrome (RLS) in a Brazilian sleep disorders center. METHODS: We retrospectively studied 118 patients with RLS from January, 2004, to December, 2010. The analyzed variables were: age at disease onset, gender, race, years of school instruction, primary and secondary RLS, and treatment options. RESULTS: Among the studied patients, 83.9% were women with a female/male sex ratio of 5:1. Mean age of the patients at symptom onset ± standard deviation was 41.7±17.9 years-old. The primary RLS was found in 85% of patients. The other 15% remainders consisted of secondary forms, and they were associated with neuropathy, iron deficiency anemia, end-stage renal disease, or Parkinson's disease. Drug therapy for RLS was introduced in 67% of patients. CONCLUSIONS: Most patients presented primary RLS with an early disease onset. Further epidemiological studies are welcomed to provide better information on secondary RLS in Brazil.

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