The T cell actin network generates mechanical forces that regulate LFA-1 activity at the immunological synapse.

The actin-binding proteins moesin and α-actinin-1 limit the lateral mobility and clustering of ICAM-1 in dendritic cells and thereby promote antigen-dependent conjugate formation and T cell priming.

CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (the CHAPLE syndrome) is caused by abnormal complement activation due to biallelic loss-of-function mutations in CD55. (Funded by the National Institute of Allergy and Infectious Diseases and others.).