The G-banding patterns of six canids, four mustelids, one hyena, and 12 felids have been studied, and data from the study of 30 felids are summarized. The canids are karyotypically very similar to one another, but minor differences have tentatively been identified. The mustelids show the greatest karyotypic diversity of all the carnivore families so far studied. They do display, however, considerable G-band conservatism, as is common throughout the Order, and appear karyotypically more closely related to the Feloidea than to the Canoidea. The hyena shares many autosomes with the felids, showing a close relationship to that family. The felids are for the first time divisible into small groups or individually identifiable on the basis of 16 different karyotypic patterns.

In the 1920s, a little girl 3 years of age was brought from China to the United States by her American mother. Although the child was beautiful, her mind was not developing. The grief-stricken mother had consulted doctors in China, but they could neither diagnose the problem nor provide treatment. Morning and night the same questions occupied her mind: "What is the matter with my little girl? What is causing it? Is there any doctor, anywhere, who can cure her?" In the United States, she also went from doctors to psychologists to clinics looking for someone who could help. Finally, she went to the Mayo Clinic in Rochester, Minnesota. When she had answered all of the doctor's questions, and all the tests were finished, they still could not tell her what was wrong. There was nothing they could do. The disease from which the little girl suffered was unknown at that time. The mother was Pearl Buck. In her book, The Child Who Never Grew,(1) she described her first infant: "I remember when she was only 3 months old she lay in her basket on the sun deck of a ship. I had taken her there for the morning air. The people who promenaded on deck often stopped to look at her, and my pride grew as they spoke of her unusual beauty and of the intelligent look of her deep, blue eyes. I do not know at what moment the growth of her intelligence stopped, nor to this day why it did." This is a classical description of the disease, phenylketonuria (PKU). A perfect infant seems to develop normally for several months, then the development slows and at some point seems to stop. "Look at Mommy-look at Daddy!" the parents say as they try to coax the treasured smiles. Instead, the child drifts into a dream world and into irreversible mental retardation. All Pearl Buck's devotion and determination was of no avail in finding the cause of her child's retardation. It was to be another mother with the same commitment to her beautiful but retarded children, who approximately 10 years later followed the same path until she found a special doctor who unlocked the secret of the fate of these children. When 1 of the authors (W.R.C.) visited Miss Buck at her Pennsylvania home in 1960, she talked about how her daughter, Carol, then a grown person, had recently been diagnosed as having PKU, as a result of screening tests at the New Jersey Vineland Training School for the Mentally Retarded. During my visit and without disclosing the reason, Pearl Buck was invited to sniff a vial of phenylacetate crystals (the odor of stale urine samples from PKU patients). Immediately she recalled that Carol, as a child, had the same unusual odor. She was relieved that the prophesy of the last words in her book had come true: "What has been, need not forever continue to be so. It is too late for some of our children, but if their plight can make people realize how unnecessary much of the tragedy is, their lives, thwarted as they are, will not have been meaningless." These could be the words of Borgny Egeland, the mother of the children through whom the mystery of PKU was b...

Pachyonychia Congenita (PC) is an autosomal dominant syndrome of thick nails and other epithelial defects. A hospitalization for severe respiratory distress in a 3-year-old boy with PC and an affected father led to the discovery of 17 affected persons in a kindred spanning four generations. Nine relatives had varying degrees of upper respiratory tract obstruction, and eleven had dental aberrations. We review PC and discuss other unusual findings in this kindred, ie, arthritis in four affected relatives and a discrepancy between expected and observed ratios of affected to unaffected offspring of mothers with PC.

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