This is the first study to describe the expression and function of SIKs in human adipocytes. Our data suggest that SIKs might be protective in the development of obesity-induced insulin resistance, with implications for future treatment strategies.

No abstract

Coordinating follow-up care after discharge from hospital is critical to ensuring good outcomes for patients, but is difficult when multiple care providers are involved. In 2018, Sweden adopted the Care Coordination Act, which modified economic incentives to reduce discharge delays and mandated a discharge planning process for patients requiring post-discharge social-or primary care services. This study evaluates the impact of this reform on hospital length-of-stay and unplanned readmissions among multi-morbid elderly patients.Interrupted time series analysis of all in-patient care episodes involving multi-morbid elderly patients in Sweden from 2015 -2019 (n = 2 386 039) was performed. Secondary analyses using case-mix adjustment and controlled interrupted time series analysis were employed to assess for bias.Average length of stay decreased during the post-reform period, corresponding to 248 521 saved care days. Unplanned readmissions meanwhile increased, corresponding to 7 572 excess unplanned readmissions. While reductions in length-of-stay were concentrated among patients targeted by the reform, increases in readmission rates were similar in patients not targeted by the reform, indicating potential confounding. The reform thus appears to have achieved its goal of decreasing in-patient length of stay, but a robust effect on readmissions, outpatient visits, or mortality was not found. This may be due to lackluster implementation or an ineffective mandated intervention.

Der ökologische Fußabdruck und der Wasserfußabdruck werden im Unterricht eingesetzt, um die Begrenztheit natürlicher Ressourcen zu thematisieren und Handlungsperspektiven im Sinne einer nachhaltigen Entwicklung zu bieten. Der Beitrag setzt sich mit unterschiedlichen Fußabdruck-Modellen auseinander und reflektiert kritisch ihre Einsatzmöglichkeiten im Unterricht.