Reconstruction of 25 to 70 percent or more of the forehead in children is best accomplished using tissue expansion and direct advancement of adjacent tissues. Simultaneous expansion should be performed in the cheek and scalp if indicated. Brow ptosis should be addressed with each advancement. Lesions greater than 70 percent of the forehead are best accomplished with distant tissues.
Cranial suture fusion in the murine model is not an "all-or-none" phenomenon. The posterior frontal suture, previously thought to be completely fused on day 45 by histological analysis, showed variable fusion along the length of the suture by both methods. Quantitative assessment of the percentage of bone within the posterior frontal and sagittal sutures and morphologic assessment of these sutures demonstrated similar findings by both methods. Whereas thorough histologic evaluation of an entire suture would be extremely labor intensive and impractical, these findings help to validate microcomputed tomography as a rapid and reliable method of examining the entire suture in murine models.
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