Background: Multidrug Resistant Tuberculosis (MDR-TB) is the biggest problem in the prevention and eradication of TB in the world. MDR TB exists in 27 countries where there are at least 6,800 MDR TB cases every year and 12% of new TB cases registered are MDR TB. MDR-TB is a disease caused by resistant Mycobacterium tuberculosis. This study aims to examine the effect of non-compliance with taking medication on the incidence of multidrug resistant tuberculosis (MDR TB). Subjects and Method:The problems of this study with PICO are as follows: Population= TB patients, Intervention = Non-compliance with taking medication. Comparison= Adherence to taking medication, and Outcome= Incidence of Multidrug Resistant Tuberculosis. Meta-analysis was carried out by systematically reviewing articles from Google Scholar, Pubmed and Springer Link. The articles used in this research are articles that have been published from 2010-2019. The keywords to look for articles are as follows: "Risk Factor MDR TB" OR "Previous Treatment" AND "Multidrug resistant tuberculosis". The inclusion criteria used were full paper, used English, case control study design and the results reported were adjusted odds ratio. Articles were collected using the PRISMA diagram and analyzed using the Review Manager 5.3 application with a fixed effect model. Results: A total of nine articles reviewed in this study came from Bangladesh, Malaysia, Pakistan and Ethiopia. This resulted in a study showing that the effect of incomplete treatment increased the risk of multidrug resistant tuberculosis (aOR= 10.04; 95% CI= 8.90 to 11.32; p <0.001). Conclusion:The effect of incomplete treatment increases the risk of multidrug resistant tuberculosis in Taiwan,
Background: Multidrug Resistant Tuberculosis (MDR-TB) is a highest problem in the prevention and eradication of TB worldwide. MDR-TB exists in 27 countries where there are at least 6,800 MDR-TB cases annually and 12% of new TB cases registered are MDR TB. This study aimed to examine the effect of incomplete medication intake on the incidence of MDR TB. Subjects and Method: Meta-analysis and systematic review was conducted by collecting articles from Google Scholar, Pubmed, and Springer Link databases, from year 2010 to 2019. Keywords used “Risk Factor MDR TB” OR “Previous Treatment” AND “Multidrug resistant tuberculosis”. The inclusion criteria were full text, using English language, using case control study design, and reporting adjusted odds ratio. The study population was patients with Tuberculosis. The intervention was incomplete medication intake with comparison complete medication intake. The study outcome was multidrug resistant Tuberculosis. Collected articles were selected by PRISMA flow chart. Quantitative data were analyzed by fixed effect model using Revman 5.3. Results: 6 studies from Taiwan, Bangladesh, Malaysia, and Ethiophia were selected for data analysis. This study reported that incomplete medication intake increased the risk of multidrug resistant tuberculosis (aOR= 14.33; 95% CI= 12.47 to 16.47; p<0.001). Conclusion: Incomplete medication intake increases the risk of multidrug resistant Tuberculosis. Keywords: incomplete medication intake, multidrug resistant tuberculosis Correspondence: Widya Kurnianingsih. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: widyakurnianingsih08@gmail.com. Mobile: 081556837033
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