Background Sickle cell Anemia and/or Disease (SCA/SCD) is an autosomal recessive disease leading to abnormal hemoglobin with global prevalence in general and tribal burden in sub-Saharan Africa particularly. Methods Recent patients’ assessments were done using routine diagnostic protocols for SCA monitoring and manifestations. Insight of the physicians towards innovative techniques at the molecular level were done to enhance medical performance of the disease investigations. The online questionnaire showed the response and acceptance levels of the physicians to introduced innovative techniques in integration with current clinical and laboratory’s spectrums. Data interpretation and statistical analysis were done using IBM-SPSS ver 25 and MS. Excel 2019. Results Clinical manifestation showed painful crises, (Hand and food syndrome) and enuresis were observed in more than half of the patients, while stroke observed only in 5.5%. A strong association was observed in males regarding Hb vs RBC and MCV vs HbA2.However. females show an association between MCV vs HbA2 only. SCA current spectrum include CBC, BF and Solubility Sickling Test showed significant results in Hemoglobin P < 0.05 and Strong association was observed between Hb vs RBC, MCV vs HbA2 for males and MCV vs HbA2 for female only. Polymerase Chain Reaction (PCR) was introduced to detect inherited polymorphic traits in infants and parents beside the flow cytometry gave a detailed informatic image for the up normal blood cells shape and amounts comparing with normal ones. The high response of the online questionnaire (100%) showed the attitude of doctors and related staff accepting innovative techniques for enhancing current health system. Conclusions Although the current clinical and laboratory diagnostic protocols are effective for diagnosing SCA, the follow-up and treatment but the approach of innovative techniques is highly demanded for detecting un-seen symptoms and hidden polymorphic traits, beside monitoring all patients with including other family members.
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