This case study presents data for operant conditioning of alpha current source density (CSD) in a 3-year-old female that completed 20 sessions of EEG LORETA neurofeedback (LNFB) to address sequelae associated with intrauterine drug exposure (IUDE), including explosive reactions to unfavorable activities and siblings, deficits in self-care, self-direction, and social interaction. One of the more difficult processes is to assess children less than 6 years of age due to extreme variability in affect, interest, and focus. However, IUDE increases the range of potential problems and diagnostic confounds. This individual showed adaptive behavior improvements ratings by parents posttraining and was able to complete a measure of attention after training and at 30-day follow-up. Her data demonstrated a general increase in the trained CSD of the alpha frequency at precuneus across time. Additional changes were evident in the self-regulation network (SRN) posttraining with a significant decrease at follow-up suggesting a learning effect over time. This case study demonstrates that LNFB may produce positive effects in children under the age of 4.
Introduction: Intrauterine drug exposure (IUDE) including neonatal abstinence syndrome (NAS) is a group of problems that occur in a newborn exposed to drugs in the womb. Currently, there is no consensus on diagnostic criteria for addressing the cluster of problems present in children suffering from IUDE. The current data sought to examine differences between IUDE and attention-deficit/hyperactivity disorder (ADHD) clients to elucidate specific differences between these groups in the Conners Continuous Performance Test (CPT-3/K-CPT) and EEG source localization data using standardized low-resolution electromagnetic brain tomography (sLORETA). Methods: This study utilizes archived data from two groups 14 IUDE and 9 clients with standing diagnosis of ADHD between the ages of 4 and 13 without the presence of fetal alcohol syndrome (FAS). All clients completed a standard protocol to assess functional domains, including diagnostic interview, review of records, and tests of attention, executive functions, and psychological status. IUDE clients at time of initial assessment were taking one or more medications. ADHD clients consisted of medicated and unmedicated individuals. Results: Significant differences were found between resting-state baseline sLORETA parameters in temporal, limbic, and precuneus regions. Conclusions: IUDE presents a growing problem in the United States due to current opioid problems, and it is imperative to accurately classify these children according to this specific set of problems. sLORETA assessment may be useful as one marker of IUDE. Directions for future treatment paradigms are discussed as well as potential applications of neurofeedback and learning.
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