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Objectives To evaluate the role of ocular vestibular evoked myogenic potentials (oVEMP) in diagnosis of vestibular abnormalities among patients with type 2 diabetes mellitus (T2DM). Methods Eighty T2DM patients were selected for the study plus a group of 30 normal non-diabetic individuals. Both groups were assessed regarding oVEMP latency and amplitude. Results There were statistically significant differences in the latencies of N1 and P1 in patients with DM in comparison to controls in both the right and left ears although there was no significant difference between both groups regarding the amplitude of N1 and P1. We found that there were statistically significant differences in the latencies of N1 and P1 in patients with DPN in comparison with patients without DPN. Also, we found that there was no significant relation between duration of diabetes and VEMP latency. According to type of treatment, there was significant difference between diabetic patients on insulin therapy and those on hypoglycemic medications regarding latency of N1 and P1 (Table 6). Conclusion In patients with type 2 DM receiving primary health care, who are not seeking medical care due to sensory or balance decline, utricular function may be impaired even without history of falls.

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Purpose:To assess the role of diffusion tensor imaging metrics in the evaluation of the microstructural integrity of the central auditory tract in patients with idiopathic sensorineural hearing loss (SNHL), and to compare these patients with healthy controls. Material and methods:This prospective study, which was conducted upon 30 subjects (21 males, 9 females; age range from 16 to 65 years, mean age 45years) with SNHL proven by audiometric tests. Ten age-and sex-matched healthy volunteers were included as a control group. Patients (n = 30) and volunteers (n = 10) underwent conventional magnetic resonance imaging and diffusion tensor imaging of the brain. Both fractional anisotropy and mean diffusivity (MD) of 3 points along the acoustic tract (inferior colliculus, lateral lemniscus and superior olivary nucleus) were measured bilaterally in all patients and correlated with controls.Results: Mean fractional anisotropy (FA) values were reduced bilaterally at the superior olivary nucleus and/or lateral lemniscus and more significantly at the inferior colliculus of subjects with SNHL in comparison to the volunteers. In patients of unilateral SNHL, similar results were obtained in the contralateral side when compared to controls with statistically significant difference at the 3 regions (p = 0.001). No significant changes were noticed in the MD parameters either in patient or control groups. Conclusions:The FA value was a valuable non-invasive biomarker in evaluating the subtle microstructural abnormalities of the central auditory tract in idiopathic SNHL and correlated well with hearing impairment.

Background:Hydroxychloroquine (HCQ) is a commonly used agent in the treatment of rheumatic diseases including systemic lupus erythematosus (SLE). [1]Objectives:The aim of this study was to evaluate the hearing function in SLE patients and assess the impact of chronic HCQ.Methods:This study was carried out on 60 individuals (48 SLE and 12 healthy controls). The SLE patients were divided into HCQ group (n=36) and non-HCQ group (n=12) according to the chronic administration of HCQ. All participants were assessed by full audiological history and extended high frequency audiometry at frequencies 9, 10, 11, 2, 12.5, 14, 16,18 and 20 KHz.Results:When comparing the study SLE patients with healthy controls,there was a statistically significant difference regarding patient reported otological manifestations such as tinnitus (p=.021), vertigo (p=.002) and hearing impairment (p=.042) while there was no significant difference regarding deafness or ear buzzing in one or both ears. HCQ group showed more hearing impairment at frequency 9000 and 20000 Hz than non-HCQ group (p=.004, <.001 respectively).Conclusion:Otological symptoms and sensorineural hearing loss are prevalent among SLE patients. Chronic administration of HCQ may have an ototoxic effect.References:[1]Fiehn, C., et al. “Safety management in treatment with antimalarials in rheumatology. Interdisciplinary recommendations on the basis of a systematic literature review.” Zeitschrift für Rheumatologie (2020): 1-9.Figure 1.Otological manifestations in the study SLE patients (n=48) and the healthy controls (n=12)Disclosure of Interests:None declared

objectives: to evaluate if there is variability in subjective perception of vertigo in diabetic patients in comparison to non-diabetic subjects. Methods: 28 patients with diabetes type 2 and 28 normal volunteers participated in the present study. Monothermal cool caloric test used to induce vertigo and visual analog scale (VAS) used to quantify the intensity the perceived caloric induced vertigo. Results: there was no significant difference between both groups in all study variables. There was a significant difference in VAS scores between both ears in diabetic group patients. Conclusion: there is abnormal vestibular performance in diabetic patients even in the presence of normal vestibular laboratory functions.