We report a method for fast Fourier transform (FFT)-weighted
optical
coherence tomography (OCT) in the second biological tissue transparency
window by actively modulating the plasmonic scattering of Fe3O4@Au hybrid nanorods using magnetic fields. Instead of
tracking the nanoparticles’ lateral displacement in conventional
magnetomotive OCT imaging, we monitor the nanorod rotation and optical
signal changes under an alternating magnetic field in real time. The
coherent rotation of the nanorods with the field produces periodic
OCT signals, and the FFT is then used to convert the periodic OCT
signals in the time domain to a single peak in the frequency domain.
This allows automatic screening of nanorod signals from the random
biological noises and reconstruction of FFT-weighted images using
a computer program based on a time-sequence image set. Compared with
conventional magnetomotive OCT, the FFT-weighted imaging technique
creates enhanced OCT images with dB-scale contrast over an order of
magnitude higher than the original images.
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