With the maturity of fault-block reservoirs, the water percolation channels are formed after long-term waterflooding, which leads to large amounts remaining oil unrecovered and low recovery efficiency. Thus, it is imperative to seek for enhancing oil recovery methods to improve the development performance of mature fault-block reservoirs. Well pattern adjustment and heterogeneous phase combined flooding are both feasible technologies for enhancing oil recovery in mature fault-block reservoirs. Nevertheless, both technologies have their limitations. Thus, a hybrid approach combining WPA and HPCF was proposed. In this study, the large-scale plate sand-pack model flooding experiments were conducted to investigate whether hybrid strategy has better EOR ability than the single WPA or HPCF. Thereafter, on the basis of incremental oil recovery and distribution of remaining oil, the mechanism of the synergistic effect of WPA and HPCF was illustrated. Finally, the influence of reservoir inclination on development performance was proposed. The results show that EOR of hybrid strategy is the highest, followed by single HPCF, and single WPA is the least. The HPCF mainly recovers remaining oil on both sides of main streamline after water flooding, and it prolongs the period of EOR validity. WPA can change the fluid flow direction and force the subsequent liquid enters the un-swept non-main streamline areas in the water flooding stage. Furthermore, by combining WPA and HPCF, the HPCF can enter the non-main streamline areas to expand sweep volume and improve oil displacement efficiency under the induction of WPA. Besides, the reservoir inclination has an obvious influence on the development performance of fault-block reservoir. With the increase of reservoir inclination, the incremental oil recovery of the single strategy or hybrid strategy decreases. Thus, these findings of this study can help for better understanding the synergetic effect of HPCF and WPA, which can provide a hybrid strategy for enhancing oil recovery in mature fault-block reservoir.