Serotonin influences mental health and well-being. To understand the influences of genetic variations in serotonin pathway on well-being, we examined the effects of seven serotonergic polymorphisms on subjective well-being (i.e. affective balance, global life satisfaction) and psychological well-being (i.e. optimal psychological functions in the face of existential challenges) in a larger sample. Results indicated that the cumulative genetic score, but single genetic effects of serotonergic polymorphisms, was related to individual differences in well-being. Specifically, individuals with a greater cumulative genetic score, which is related to a low risk of depression, tended to show high levels of subjective well-being and psychological well-being. These findings suggest that the overall serotoninergic genetic profile, rather than a specific genetic polymorphism, could greatly influence the individual differences in well-being.
Alexithymia is a subclinical personality disorder characterized by difficulties in identifying and expressing one's own emotion. Individual differences in alexithymia are influenced by both genetic and environmental factors. However, the interplay between these factors and their influences on alexithymia are unclear. Considering that oxytocin plays important roles in emotion processing and that parental bonding influences the development of alexithymia, we explored the associations between OXTR polymorphisms and alexithymia and examined whether the potential associations are moderated by parental bonding. To this end, we genotyped the OXTR polymorphisms (rs53576 and rs1042778) and scored alexithymia and parental bonding with the Toronto Alexithymia Scale and the Parental Bonding Instrument. Results indicated that: (1) the characteristics of alexithymia were negatively associated with parental care and positively with parental overprotection; (2) the OXTR rs53576 was significantly associated with the characteristics of alexithymia, such that the AA genotype was associated with fewer difficulties in identifying feelings and describing feelings than the AG/GG genotypes; and (3) the OXTR rs1042778 interacted with parental care in alexithymia with the vantage sensitivity model: the GG genotype was related to less severity of alexithymia than the AG/GG genotypes only in individuals with higher parental care. Overall, these findings suggest that the OXTR is related to alexithymia and that the quality of parental care influences the relationship. However, considering that the evidence from this study is weak, more research is needed to understand the roles of OXTR in alexithymia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.