Carbonate. -In comparison with reported procedures for sulfenylation of indoles (I), the present method is not moisture sensitive and carried out in the green solvent dimethyl carbonate. It is noteworthy that both of the sulfenyl groups of a symmetric disulfide (II) take part in the reaction.

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An aerobic CeCl3·7H2O/NaI‐catalyzed C–H functionalization reaction was developed for the synthesis of 3‐sulfenylimidazo[1,2‐a]pyridines from easily available ketones, 2‐aminopyridines, and disulfides without DMSO or peroxide as an oxidant. This three‐component tandem reaction process involves the formation of imidazo[1,2‐a]pyridines followed by Friedel–Crafts sulfenylation in one pot under mild conditions. Both aryl and alkyl ketones afforded the desired products in good to excellent yields without the presence of other additives.

Iodine-catalyzed intermolecular dehydrogenative aromatizations of six-membered cyclohexanA C H T U N G T R E N N U N G ones for the selective synthesis of 2-sulfanylphenols have been developed. Both aryl and alkyl disulfides can be used as sulfanylation reagents to give the desired products in good yields under the optimized reaction conditions. The catalytic reaction uses dimethyl sulfoxide or oxygen as the terminal oxidant and avoids the use of transition metal catalysts. In addition, a-sulfanyl enones could also be obtained via an iodine-catalyzed oxidative system from simple cyclic ketones using dimethyl sulfoxide as the oxidant.

A highly efficient protocol for the synthesis of 3-sulfenylindoles in moderate to excellent yields via the reaction of indoles with unsymmetric benzothiazolyl-containing disulfides is described. Copper(I) iodide is used as the catalyst and the reactions take place at room temperature. The by-product, 2-mercaptobenzothiazole, can be easily recovered and reused.

Iodine-Catalyzed Selective Synthesis of 2-Sulfanylphenols via Oxidative Aromatization of Cyclohexanones and Disulfides.-Both aryl and alkyl disulfides are employed as sulfanylation reagents to give the desired products in good yields under the optimized reaction conditions. The catalytic reaction proceeds in the presence of dimethyl sulfoxide or oxygen as the terminal oxidant and avoids the use of transition metal catalysts. In addition, α-sulfanyl enones are obtained via an iodine-catalyzed oxidative system from simple cyclic ketones using dimethyl sulfoxide as the oxidant. -(GE, W.; ZHU*, X.; WEI, Y.; Adv. Synth. Catal. 355 (2013) 14-15, 3014-3021, http://dx.

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Temperature. -The simple method allows an efficient access to sulfurated indole derivatives of medicinal interest. The by-product mercaptobenzothiazole can easily be recovered and reused for a new preparation of disulfide substrates. -(GE, W.; WEI*, Y.; Synthesis 2012, 6, 934-940, http://dx.