Sweat
wearable sensors enable noninvasive and real-time metabolite
monitoring in human health management but lack accuracy and wearable
applicability. The rational design of sensing electrode materials
will be critical yet challenging. Herein, we report a dual aerogel-based
nonenzymatic wearable sensor for the sensitive and selective detection
of uric acid (UA) in human sweat. The three-dimensional porous dual-structural
aerogels composed of Au nanowires and N-doped graphene nanosheets
(noted as N-rGO/Au DAs) provide a large active surface, abundant access
to the target, rapid electron transfer pathways, and a high intrinsic
activity. Thus, a direct UA electro-oxidation is demonstrated at the
N-rGO/Au DAs with a much higher activity than those at the individual
gels (i.e., Au and N-rGO). Moreover, the resulting sensing chip displays
high performance with a good anti-interfering ability, long-term stability,
and excellent flexibility toward the UA detection. With the assistance
of a wireless circuit, a wearable sensor is successfully applied in
the real-time UA monitoring on human skin. The obtained result is
comparable to that evaluated by high-performance liquid chromatography.
This dual aerogel-based nonenzymatic biosensing platform not only
holds considerable promise for the reliable sweat metabolite monitoring
but also opens an avenue for metal-based aerogels as flexible electrodes
in wearable sensing.
Improving the utilization of noble metals is of huge urgency for fuel cell electrocatalysis, while three-dimensional hierarchical noble metal aerogels with abundant sites and channels are proposed to reinforce their...
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