Pterygium is a common ophthalmic disease affecting humans only. Extensive epidemiological data have demonstrated a causative effect of chronic ultraviolet (UV) radiation on pterygia. Progress has been made in determining the origin of pterygia, their nasal predilection and wing‑shaped appearance, and the roles of UV radiation in the initiation and the development of pterygia. In the present review, the current understanding of the involvement of UV radiation in the pathogenesis of pterygia is summarized. This involvement includes the alteration of limbal stem cells and fibroblasts that contribute to the initiation of pterygia and the induction of various pro‑inflammatory cytokines, growth factors and matrix metalloproteinases that promote the progression of pterygia. Further elucidation of the roles of UV radiation in the pathogenesis of pterygia may help to encourage individuals at risk of developing pterygia to take preventive measures and aid researchers in the development of novel targeted therapeutic agents to treat pterygia.

The technique of computational fluid dynamics (CFD) was used to study the concentrations and distributions of indoor radon (222Rn) and thoron (220Rn) as well as their progeny in three dimensions. According to the simulation results, in a naturally ventilated room, the activity distribution of 222Rn is homogeneous except for the places near air diffuser (supply and exhaust) locations. The concentration of 220Rn exponentially decreases with the distance from the source wall which is considered independently. However, as the ventilation rate increased, the concentrations of both 222Rn and 220Rn decreased and their activity distributions become complicated due to the effect of turbulent flow. It suggests that the impact factors of monitoring conditions (sampling site, airflow characteristics, etc.) should be taken into account in obtaining representative concentrations of 222Rn/220Rn for dose assessment. Both the simulation results of activities and their distributions agreed well with the experimental results in a laboratory room. It suggests that the CFD models may be applicable for the estimation of indoor 222Rn and 220Rn as well as their progeny.

Background Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains the primary cause of death in patients with breast cancer. Basal-like breast cancer (BLBC) is associated with aggressive behavior, stem-like phenotype, high histological grade, poor clinical features, and high rates of recurrences and/or metastasis. However, the mechanism of BLBC phenotype shaping remains obscure. Methods Seventeen normal breast/breast cancer cell lines were used for evaluating the breast cancer subtype-markers, WNT targets and constitutive components, and epithelial mesenchymal transition (EMT) markers analysis by western blot. One hundred and twenty formalin-fixed breast cancer tissues were used for immunohistochemistry (IHC) staining. Nine online platforms (cBioPortal, CCLE, GEPIA, etc.) were used for related analyses. Results We identified Wnt5b as a key regulatory factor that governs the phenotype of BLBC by activating canonical and non-canonical WNT signaling. Wnt5b exhibited basal-like specificity in cells and clinical samples both at the mRNA and protein levels and also showed good correlation with basal-like phenotype at the mRNA level. Besides, Wnt5b was also a promising therapeutic target for LGK-974 treatment. In addition, we identified that CK1α was expressed at low levels in BLBC and that the activation of CK1α by pyrvinium was an alternative strategy for BLBC treatment. Conclusions Wnt5b is not only a diagnostic biomarker but also a potential therapeutic target of BLBC. Graphical abstract Electronic supplementary material The online version of this article (10.1186/s12964-019-0419-2) contains supplementary material, which is available to authorized users.