Production or elimination of highly reactive oxygen species is critical in antioxidant, photodynamic, therapeutic, and antibacterial applications. Recent studies have demonstrated that graphene quantum dots (GQDs) possess anti- and pro-oxidant properties simultaneously. However, their efficiency is low. Here, we report chlorine-doped GQDs (Cl-GQDs) with a tunable Cl doping amount and improved anti- and pro-oxidant activities. The scavenging performance and the free radical-produced efficiency of Cl-GQDs are about 7-fold and 3-fold, respectively, higher than those of the undoped GQDs. Meanwhile, Cl-GQDs are considered to be promising for antibacterial applications because of their enhanced singlet oxygen generating ability. We hope that this study could provide a new strategy to develop nanomaterials for application in the anti- and pro-oxidant field.

The development of new antioxidants with quick absorbance of free radicals and excellent biocompatibility has drawn intensive attention in recent years.

MXene quantum dots feature favorable biological compatibility and superior optical properties, offering great potential for biomedical applications such as reactive oxygen species (ROS) scavenging and fluorescence sensing. However, the ROS scavenging mechanism is still unclear and the MXene-based materials for ROS sensing are still scarce. Here, we report a nitrogen-doped titanium carbide quantum dot (N-Ti3C2 QD) antioxidant with effective ROS scavenging ability. The doped nitrogen atoms promote the electrochemical interaction between N-Ti3C2 QDs and free radicals and thus enhance their antioxidant performance. Density functional theory (DFT) simulations reveal the hydroxyl radical quenching process and confirm that the doped N element promotes the free-radical absorption ability, especially for −F and −O functional groups in N-Ti3C2 QDs. Furthermore, N-Ti3C2 QDs show rapid, accurate, and remarkable sensitivity to hydrogen peroxide in the range of 5 nM–5.5 μM with a limit of detection of 1.2 nM within 15 s, which is the lowest detection limit of the existing fluorescent probes up to now. Our results provide a new category of antioxidant materials, a real-time hydrogen peroxide sensing probe, promoting the research and development of MXene in bioscience and biotechnology.

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