The adulteration by synthetic therapeutic substances of traditional Chinese medicines has been reported on various occasions and has been a public health concern in Taiwan over the past several years. A large-scale effort was initiated in 1992 to screen traditional Chinese medicines that were suspected of adulteration with synthetic therapeutic substances. The term "adulteration" refers to traditional Chinese medicines that are tested and found to contain chemical substances not prescribed or labeled as part of the intended use. A total of 2,609 samples were collected by eight major general hospitals in Taiwan. Samples were collected through physicians' referrals during patients visits. The samples were analyzed by hospital pharmacists following the established standard procedures in comparison to references by thin-layer chromatography. An average of 23.7% (n = 618) of the samples collected from the eight hospitals were adulterated. Four samples with either a rheumatoid or an antiinflammatory indication contained six different kinds of adulterants. More than half (52.8%) of the adulterated traditional Chinese medicines contained two or more adulterants. The sources of adulterated samples and their claimed indications, as well as the most frequently detected synthetic therapeutic substances, are presented in this report. The controversies regarding the combination of synthetic therapeutic substances and traditional Chinese medicines without adequate labeling should be resolved through regulatory actions for better safety of drug use.
Long-term exposures to pioglitazone and rosiglitazone were associated with higher odds of bladder cancer, and the highest odds were seen in users with ≥ 2 years of exposure.
Objectives. To survey the knowledge, attitudes, and practices towards safe medication use of first-year college students in Taiwan. Methods. One hundred forty-seven departments in 27 universities were sampled by stratified randomization. Three sections of the questionnaire were developed, including 10 true/false questions to measure knowledge, 4 questions for attitude in a 5-point scale, and 10 questions for practice in a 5-point scale.Results. A total of 6270 subjects completed the survey instrument for a valid response rate of 91.9%. Students who were health science majors had safer medication practices than non-health science majors. However, students in both groups had low scores on appropriate antibiotics use, with a correctness rate of 45.8%. Knowledge relating to antacid use had the lowest number of correct responses among the 10 items included in the survey. Overall, the students showed positive attitudes toward (12.6 6 2.2) and trusted (3.6 6 0.7) pharmacists' consultation. Conclusions. College students lack appropriate knowledge, attitudes, and practices related to the safe use of medications, and efforts are warranted in Taiwan.
Our findings suggest that although the use of clopidogrel plus PPIs provides GI benefits, with this treatment, there is an increased CV risk among patients with a history of GI bleeding.
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