Background: Stereotactic body radiation therapy (SBRT) is a non-invasive treatment option for metastatic cancer. The purpose of our study was to investigate the efficacy and safety of SBRT for patients with pulmonary or hepatic metastases. Methods:We retrospectively reviewed patients treated with SBRT between 2013 and 2019. Previous local or systemic treatments were allowed. Our end points were the outcomes in terms of local control (LC) of treated metastases, overall survival (OS), and treatment toxicities. The significance of each prognostic factor was estimated using survival analysis.Results: Fifty-one patients and 181 metastatic lesions were analyzed. The median follow-up time was 18 months and the median patient age was 60 years old. The predominant origins of primary cancers include hepatocellular carcinoma (HCC) (21.6%) and colorectal cancer (19.6%), followed by breast cancer (15.7%), nonsmall cell lung cancer (NSCLC) (7.8%), nasopharyngeal cancer (NPC) (7.8%), and others (21.6%). The most common prescribed doses were 50 Gy in 5 fractions (62.4%) and 60 Gy in 5 fractions (31.5%). The 1-and 2-year LC rates were 95.4% and 85.8%. The 1-and 2-year OS rate were 72.9% and 45.1% while the median OS was 24 months. The HCC origin group had worse LC (HR 3.12, P=0.039) and more than 3 treated lesions (HR 3.28, P=0.008) was negatively impacting the OS. In no events the acute or late toxicities were more than grade 3. Conclusions:The results of our study suggest that SBRT offers a feasible treatment with low toxicities and achieves high rates of LC for pulmonary or hepatic metastases.
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