Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.
In order to study the influence of interface bond condition between new and old cement concrete pavement on overlay performance, the three-dimensional finite element model of the airport double-layer pavement was established. The pavement overlay's load stress and deflection were analyzed, the coupling coefficient between new and old cement concrete pavement was calculated based on the bottom of overlay deflection basin shape factor. The results show that the coupling coefficient reflects the degrees of interface bond condition well. Poor interface bond condition increases the overlay's load stress and deflection. The points that more closely distance from the wheels load center, the bigger the pavement overlay's load stress and deflection is. Therefore, more attention should be paid to the interface bond condition during the airport pavement overlay's designs and constructions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.