One may discover a stone tool by chance but it takes more than luck to make a car or cell phone. With the advance of nanoscience, the synthesis of increasingly sophisticated nanostructures demands a rational design and a systems approach. In this Review, we advocate the distinction between thermodynamically and kinetically controlled scenarios, that is, whether a product forms because it is the most stable state or because the pathway leading to it has the lowest energy barrier. Great endeavours have been made to describe the multiple concurrent processes in typical nanosynthesis phenomena, so that the mechanistic proposals in the literature are brought into a common framework for easy contrast and comparison.

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Hydrophobic carbon nanotubes (CNTs) and hydrophilic nanofilaments such as oxidized CNTs, Pd nanowires (NWs), and MnO(2) NWs are transformed from wires to rings by a general methodology. We show that both oil-in-water and water-in-oil emulsions, so long as their droplet size is sufficiently small, can exert significant force to the entrapped nanostructures, causing their deformation. This effect can be easily achieved by simply mixing a few solutions in correct ratios. Even preformed oil droplets can take in CNTs from the aqueous solution converting them into rings, indicating the important role of thermodynamics: The question here is not if the droplets can exert sufficient force to bend the nanofilaments, because their random vibration may be already doing it. As long as the difference in solvation energy is large enough for a nanofilament, it would "want" to move away from the bulk solution and fit inside tiny droplets, even at the cost of induced strain energy. That said, the specific interactions between a droplet and a filament are also of importance. For example, when an oil droplet rapidly shrinks in size, it can compress the entrapped CNTs in multiple stages into structures with higher curvatures (thus higher strain) than that of a circular ring, which has minimal induced strain inside a spherical droplet.

Amphiphilic block copolymers such as polystyrene-block-poly(acrylic acid) (PSPAA) give micelles that are known to undergo sphere-to-cylinder shape transformation. Exploiting this polymer property, core-shell nanoparticles coated in PSPAA can be "polymerized" into long chains following the chain-growth polymerization mode. This method is now extended to include a variety of different nanoparticles. A case study on the assembly process was carried out to understand the influence of the PAA block length, the surface ligand, and the size and morphology of the monomer nanoparticles. Shortening the PAA block promotes the reorganization of the amphiphilic copolymer in the micelles, which is essential for assembling large Au nanoparticles. Small Au nanoparticles can be directly "copolymerized" with empty PSPAA micelles into chains. The reaction time, acid quantity, and the [Au nanoparticles]/[PSPAA micelles] concentration ratio played important roles in controlling the sphere-cylinder-vesicle conversion of the PSPAA micelles, giving rise to different kinds of random "copolymers". With this knowledge, a general method is then developed to synthesize homo, random, and block "copolymers", where the basic units include small Au nanoparticles (d = 16 nm), large Au nanoparticles (d = 32 nm), Au nanorods, Te nanowires, and carbon nanotubes. Given the lack of means for assembling nanoparticles, advancing synthetic capabilities is of crucial importance. Our work provides convenient routes for combining nanoparticles into long-chain structures, facilitating rational design of complex nanostructures in the future.

World's smallest screws with helical threads are synthesized via mild etching of Ag nanowires. With detailed characterization, we show that this nanostructure arises not from the transformation of the initial lattice, but the result of a unique etching mode. Three-dimensional printed models are used to illustrate the evolution of etch pits, from which a possible mechanism is postulated.

Magnetic nanorobots are used as nanometer‐size stir bars for rapid stirring inside ultrasmall volumes of fluids. Because of their small size and rapid stirring, they can generate many vortexes inside confined small droplets. It is shown that these vortexes can vigorously churn up large microparticles without destabilizing or moving the droplets. The vortex formation can be easily controlled by tuning the stirring rate of nano stir bars using a simple magnetic stirrer.

Multifarious organic phase droplets have emerged in diverse applications such as material synthesis and biological pharmacy; accordingly, the organic droplet generation demands more on the usability and the controllability. In this article, we demonstrate a universal and simple method to actively generate organic in water (O/W) droplet in a poly­(dimethylsiloxane) (PDMS)-based microfluidics device by using both DC and AC electric fields to cut a stable layered flow of the disperse phase into dispersed droplets or liquid slugs in a precise manner. The system demonstrates the feature of ultrafast response and precise control of O/W droplet generation. The biggest advantage of the proposed approach is that it removes the necessity for surface treatment in conventional O/W droplet formation in PDMS microchannels, breaking the limits brought by the surface wettability for the first time and rendering itself to be a universal method for O/W droplet generation. We also explored the breakup of the disperse phase, catalogued them into three stages with sinusoidal AC electric fields, namely, nonbreakup, transition, and continuous breakup and mapped the voltage boundaries in these stages. To demonstrate their general application to generate organic droplets, we executed these control strategies on four typical organic fluids, each flowing with different hydrodynamic characteristics. The results showed precise cutting and tuning effects from the square and the sinusoidal wave electric fields. Our findings propose a potentially universal active formation technique for the organic-based solutions droplet and widen the applications of the microfluidics.

Depending on the synthetic methods, bimetallic nanoparticles can have either core-shell, phase segregated, alloy, or partially coalesced structures, presenting different degrees of atomic mixing on their surface. Along with the variations of size and morphology, the structural differences make it difficult to compare the catalytic activity of bimetallic nanoparticles. In this article, we developed a facile screening method that can focus on the synergistic effects rather than structural differences. Prefabricated nanoparticles are mixed together to form linear aggregates and coalesced to form bimetallic junctions. Their hollow silica shells allow materials transport but prevent further aggregation. With a level playing field, this screening platform can identify the best bimetallic combination for a catalytic reaction, before optimizing the synthesis. This approach is more advantageous than the conventional approaches where structural difference may have dominant effects on the catalytic performance.