We herein describe an efficient iron‐catalyzed selective N‐methylation and N‐formylation of amines with CO2 and silane using mono‐phosphine as ligand. With commercially available [CpFe(CO)2]2 as catalyst, Fe‐catalyzed methylation of amines was achieved with triphenylphosphine as a ligand. Using tributylphosphine as a ligand, Fe‐catalyzed formylation of amines was realized at a lower temperature. The method was successfully applied in the late‐stage methylation and formylation of drug molecules containing amine moiety.magnified image
We report here a
Ni-catalyzed reductive coupling of aldehydes with
widely available 1,3-dienes under visible-light photoredox dual catalysis.
The homoallyic alcohols are obtained in broad scope with complete
branched regioselectivity. Hantzsch ester is used as the hydrogen
radical source to oxidize low-valent nickel salt affording Ni–H
species. Preliminary mechanistic studies indicate a successive single-electron
transfer (SET) pathway and the generation of a key π-allylnickel
intermediate via Ni–H insertion of 1,3-diene in this synergistic
catalytic process.
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