In the present research analysis we have addressed comparative investigation of radiative electrically conducting Casson nanofluid. Nanofluid Flow is assumed over a nonlinearly stretching sheet. Heat transport analysis is carried via joule dissipation, thermal behavior and convective boundary condition. To employ the radiative effect radiation was involved to show the diverse states of nanoparticles. Furthermore entropy optimization with activation energy and chemical reaction are considered. Thermodynamics 2 nd law is applied to explore entropy generation rate. Nonlinear expression is simplified through similarity variables. The reduced ordinary system is tackled through optimal approach. Flow pattern was reported for wide range of scrutinized parameters. Computational consequences of velocity drag force, heat flux and concentration gradient are analyzed numerically in tables. Results verify that conduction mode augments with enhance of magnetic parameter. Increasing radiation boosts the temperature and entropy. Activation energy corresponds to augmented concentration. Heat transmission rate augments with the consideration of radiation source term. The researcher has grown consideration in the non-Newtonian fluids due to their remarkable features in the area of technological and industrial sciences. For instance, synthetic lubricants, drilling muds, certain oils, paints, sugar solutions, clay coating, and biological fluid like blood are the just communal cases of non-Newtonian fluids. The Navier-Stokes fundamental equations cannot momentarily define the characteristics of the flow field of non-Newtonian fluids due to the complexity in the mathematical formulation of the flow problem. Abundant models for non-Newtonian fluids are defined as deliberate rheological qualities such as Eyring-Powell, Bulky, Seely, Oldroyd-B, Maxwell, Oldroyd-A, Carreau, Casson, Burger, Jeffrey, etc. Amongst these models, the most significant model for the blood properties and suspensions in our daily life is the Casson model 1. For the purpose of developments in fluids study, considering Soret and Dufour effects, Hayat et al. 2 proposed the flow of Casson fluid. The details research work about Casson fluid can be seen in 3-6. Saravana et al. 7 have been studied magnetohydrodynamic Casson fluid with inconstant thickness under the aligned magnetic field. Due to its frequent uses in engineering and industrial, the theme of nanofluidic flow has attracted widespread attention over the past two decades. Researchers and scientists have not only discovered the astonishing thermal properties of nanofluids, but improving the causes of thermal conductivity of nanofluids are also planned, the integration of biotechnological mechanisms and nanofluids may provide capable applications in biosensors, agriculture and pharmaceuticals. In the biotechnology field, there are many nanomaterials in practice, such as