in Wiley Online Library (wileyonlinelibrary.com).We report herein the design, synthesis, and in vitro anti-tumor activities of a series of 1,2,3-triazoletetraethylene glycol tethered heteronuclear bis-Schiff base derivatives of isatin. Our results indicated that all the synthesized bis-Schiff bases except 9e showed considerable in vitro anticancer activities against HepG2, Hela, HCT-116, A549, and MCF-7 human cancer cell lines with IC 50 in a range of 9.79-48.75 μM and were more potent than etoposide against Hela, HCT-116, and A549 cell lines. In particular, the most potent bis-Schiff base 9g (IC 50 : 9.79-29.64 μg/mL) was highly active against the five cancer cell lines tested, could act as a lead for further optimization.
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