Background and Objective: The incidence of incision infection after lung transplantation is prominently high which affect the prognosis. Summarizing the risk factors related to incision infection after lung transplantation contribute to the control of incision infection by pre-controlling the risk factors. The objective is to summarize risk factors related to wound infection after lung transplantation.Methods: PubMed was used to research the literature relating to the risk factors to incision infection after lung transplantation through 1990 to 2022. The retrieval strategy were Medical Subject Heading (MeSH) terms combined entry terms. Two researchers conducted the literature retrieval independently. Two researchers independently evaluate the quality of the literature and summarize the indicators.
Objective Osteoarthritis (OA) is characterized by synovial cartilage degeneration and is the leading cause of disability and pain worldwide. This study sought to investigate the expression of integrin beta-2 (ITGB2) in synovial fluid of OA patients and its clinical significance. Methods A total of 110 OA patients were enrolled, who were classified into grade I ( N = 35), II ( N = 42), and III ( N = 33) according to the Kellgren-Lawrence classification, with 110 healthy subjects as controls, and their clinical data were compared. ITGB2 level was detected by RT-qPCR. The receiver operating characteristic curve was used to analyze the predictive value of ITGB2 on OA occurrence. The correlation between ITGB2 and bone metabolism indexes procollagen type I N-terminal peptide (PINP), bone glaprotein (BGP), bone alkaline phosphatase (BALP), and β-collagen I telopeptide (β-CTX) was analyzed by the Pearson method. Logistic regression model was performed to analyze the influencing factors of OA. Results The content of red blood cells, white blood cells, PINP, BGP, and BALP was lowered in OA patients, while β-CTX was elevated. ITGB2 was highly-expressed in OA patients, negatively-correlated with PINP, BGP, and BALP, but positively-correlated with β-CTX. ITGB2 level increased with the elevation of OA grade. The ITGB2 level >1.375 had certain diagnostic values for OA. ITGB2 level is related to OA severity and may be a biomarker for OA classification. ITGB2 was an independent risk factor for OA. Conclusion High expression of ITGB2 in synovial fluid can assist OA diagnosis and may be a biomarker for OA grade.
Background: Recurrence after antifungal therapy is a challenging complication of pulmonary aspergillosis (PA). However, the exact factors associated with the recurrence of PA are still unclear. The aim of this study was to develop and validate a Cox model nomogram for the prediction of the recurrence of PA after antifungal therapy.Methods: A total of 105 patients with PA were enrolled in this retrospective cohort study from January 2018 to December 2020 and followed up at least 12 month. The risk factors for the recurrence of PA were identified and the prediction model was developed using R software. Results: All 105 patients received effective antifungal therapy during their first admission; PA recurred in 18 patients during the follow-up period (mean, 5.5±5.2 months). Cox univariate analysis showed that immune deficiency, C-reactive protein level, galactomannan test (GM test), wheezing, pleural thickening, lung nodules, and prednisone therapy were prognostic factors for overall recurrence of PA after antifungal therapy (P<0.1). Multivariate Cox analysis indicated that pleural thickening and prednisone therapy were independent risk factors for the recurrence of PA (P<0.05). The nomogram plot was constructed based on the results of the univariate and multivariate analyses. The C-index of the predictive model was 0.90, 0.83, 0.81, and 0.81 for the 2- , 4-, 6-, and 8- month follow-up timepoints, respectively. The area under the receiver operating characteristic curve was 0.78, 0.63, and 0.61 for the 3-, 6-, and 12-month follow-up timepoints, respectively. The calibration curve showed a consistent tendency with the actual curve for the 3-month and 6-month follow-up timepoints.Conclusion: Pleural thickening on computed tomography images and prednisone therapy are independent predictive factors for the recurrence of PA after antifungal therapy. The nomogram developed in this study provided accurate individualized estimates for predicting the recurrence of PA.
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