The total control range of asymmetric dual three-phase permanent magnet synchronous motor (ADT_PMSM) is divided into three different segments by voltage modulation range and current control dimensions and respective control strategies to get the injected voltages in harmonic subspace for three segments are presented in this paper. The three segments are sinusoidal current modulation region, sinusoidal voltage modulation region and overmodulation region. In sinusoidal current modulation region, resonant controller is adopted in the harmonic subspace to calculate the injected voltages, which can compensate the effect of six-phase voltage source inverter (VSI) dead time for two sets of three-phase windings and takes the pole correction into consideration. In sinusoidal voltage modulation region, open loop control strategy in harmonic subspace is adopted. Overmodulation region 1 and 2 are defined in overmodulation region, and the harmonic voltages which are injected into harmonic subspace to extend the modulation index are calculated based on superposition principle and VSD theory. In order to achieve smooth transition from different regions, a novel space vector pulse width modulation (SVPWM) technique for ADT_PMSM is proposed. The experimental results demonstrate the validity and feasibility of the suggested control approach.

Via the vector space decomposition (VSD) transformation, the currents in an asymmetric six-phase permanent magnet synchronous motor (ASP_PMSM) can be decoupled into three orthogonal subspaces. Control of α–β currents in α–β subspace is important for torque regulation, while control of x-y currents in x-y subspace can suppress the harmonics due to the dead time of converters and other nonlinear factors. The zero-sequence components in O1-O2 subspace are 0 due to isolated neutral points. In α–β subspace, a state observer is constructed by introducing the error variable between the real current and the internal model current based on the internal model control method, which can improve the current control performance compared to the traditional internal model control method. In x–y subspace, in order to suppress the current harmonics, an adaptive-linear-neuron (ADALINE)-based control algorithm is employed to generate the compensation voltage, which is self-tuned by minimizing the estimated current distortion through the least mean square (LMS) algorithm. The modulation technique to implement the four-dimensional current control based on the three-phase SVPWM is given. The experimental results validate the robustness and effectiveness of the proposed control method.

Four‐dimension current control for asymmetric dual three‐phase permanent magnet synchronous motor based on vector space decomposition approach can eliminate the harmonic currents induced by the nonlinear characteristics of inverter. This study proposes a control strategy which uses a combination of the dead‐time compensation scheme and current harmonic elimination algorithm together to eliminate the harmonic currents. The dead‐time compensation is calculated based on the analysis of the non‐linear characteristics of the inverter. Besides, a resonant controller which takes into account the pole correction caused by the discretisation process is employed in harmonic subspace as the feedback current control loop to generate the compensation voltage. In addition the phase lag caused by the pulse width modulation update and inductive load is also considered to ensure the stability of resonant controller. The experimental results demonstrate the superior performance of the proposed scheme.

<div>Abstract<p>A distinct feature of malignant gliomas is the intrinsic ability of single tumor cells to disperse throughout the brain, contributing to the failure of existing therapies to alter the progression and recurrence of these deadly brain tumors. Regrettably, the mechanisms underlying the inherent invasiveness of glioma cells are poorly understood. Here, we report for the first time that engulfment and cell motility 1 (ELMO1) and dedicator of cytokinesis 1 (Dock180), a bipartite Rac1 guanine nucleotide exchange factor (GEF), are evidently linked to the invasive phenotype of glioma cells. Immunohistochemical analysis of primary human glioma specimens showed high expression levels of ELMO1 and Dock180 in actively invading tumor cells in the invasive areas, but not in the central regions of these tumors. Elevated expression of ELMO1 and Dock180 was also found in various human glioma cell lines compared with normal human astrocytes. Inhibition of endogenous ELMO1 and Dock180 expression significantly impeded glioma cell invasion <i>in vitro</i> and in brain tissue slices with a concomitant reduction in Rac1 activation. Conversely, exogenous expression of ELMO1 and Dock180 in glioma cells with low level endogenous expression increased their migratory and invasive capacity <i>in vitro</i> and in brain tissue. These data suggest that the bipartite GEF, ELMO1 and Dock180, play an important role in promoting cancer cell invasion and could be potential therapeutic targets for the treatment of diffuse malignant gliomas. [Cancer Res 2007;67(15):7203–11]</p></div>

<div>Abstract<p>A distinct feature of malignant gliomas is the intrinsic ability of single tumor cells to disperse throughout the brain, contributing to the failure of existing therapies to alter the progression and recurrence of these deadly brain tumors. Regrettably, the mechanisms underlying the inherent invasiveness of glioma cells are poorly understood. Here, we report for the first time that engulfment and cell motility 1 (ELMO1) and dedicator of cytokinesis 1 (Dock180), a bipartite Rac1 guanine nucleotide exchange factor (GEF), are evidently linked to the invasive phenotype of glioma cells. Immunohistochemical analysis of primary human glioma specimens showed high expression levels of ELMO1 and Dock180 in actively invading tumor cells in the invasive areas, but not in the central regions of these tumors. Elevated expression of ELMO1 and Dock180 was also found in various human glioma cell lines compared with normal human astrocytes. Inhibition of endogenous ELMO1 and Dock180 expression significantly impeded glioma cell invasion <i>in vitro</i> and in brain tissue slices with a concomitant reduction in Rac1 activation. Conversely, exogenous expression of ELMO1 and Dock180 in glioma cells with low level endogenous expression increased their migratory and invasive capacity <i>in vitro</i> and in brain tissue. These data suggest that the bipartite GEF, ELMO1 and Dock180, play an important role in promoting cancer cell invasion and could be potential therapeutic targets for the treatment of diffuse malignant gliomas. [Cancer Res 2007;67(15):7203–11]</p></div>

Supplementary Figures 1-3, Table 1 from ELMO1 and Dock180, a Bipartite Rac1 Guanine Nucleotide Exchange Factor, Promote Human Glioma Cell Invasion

This paper gives the current regulator design for a dual Y shift 30 degrees permanent magnet synchronous motor (DT_PMSM) based on the vector space decomposition (VSD). Current regulator design in α-β subspace is insufficient and designing additional controllers in x-y subspace is necessary to eliminate the harmonic currents due to the nonlinear characteristics of the inverter. A sliding mode controller based on an internal model is proposed in α-β subspace, which is robust to the parameter uncertainties and disturbances in current control loops. In order to eliminate the harmonic currents in x-y subspace, a resonant controller is employed based on a new synchronous rotating matrix. Three-phase decomposition space vector pulse width modulation (SVPWM) technique is illustrated for the purpose of synthesizing the voltage vectors in both subspaces simultaneously. The feasibility and efficiency of the suggested current regulator design are validated by a set of experimental results.

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