A range of polysubstituted furans were synthesized from furan derivatives involving copper-catalyzed ring opening of the furan ring. This synthetic method possesses the advantages of readily available starting materials, mild reaction conditions, and short steps.
We achieved sulfonated 4H-3,1-benzoxazines under ambient conditions without any metals and external chemical oxidants via electrochemical radical cascade cyclizations.
A new method for the synthesis of vinyl trifluoromethyl compounds from α, β-unsaturated carboxylic acids and CF 3 SO 2 Na has been developed. This electrochemical decarboxylative trifluoro-methylation was found to be highly stereo-selective and afforded products in good yields with wide substrate scope under metal-free and external chemical oxidant-free conditions.
Results and DiscussionTo start our investigation, p-methoxycinnamic acid (1 a) and CF 3 SO 2 Na (2) were chosen as model substrates. Under constant current at 5 mA and using LiClO 4 as supporting electrolyte in an [a] F.
Iminyl radicals are reactive intermediates which can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of a-imino-oxy acids for the generation of iminyl radicals has...
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