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The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated. The present study investigated the function of heat shock protein 27 (Hsp27) on the invasion and proliferation of CRC cells. The clinical significance of Hsp27 was evaluated using tissue microarray analysis (n=81). Invasion and metastasis assays were used to determine the function of Hsp27 in CRC metastasis and using RNA interference and the ectopic expression of Hsp27. The upregulation of Hsp27 has been frequently identified in CRC tissues. Patients with CRC and a high expression level of Hsp27 have a reduced overall survival rate. Silencing Hsp27 inhibited the growth and invasion of CRC cells and, whereas ectopic overexpression of Hsp27 promoted the proliferation and invasion of CRC cells . Furthermore, depletion of Hsp27 expression inhibited the epithelial-to-mesenchymal transition (EMT), whilst ectopic overexpression of Hsp27 induced EMT. The results of the present study indicated that Hsp27 serves an important function in the aggressiveness of CRC through inducing EMT. Hsp27 suppression may represent a potential therapeutic option for the suppression of CRC progression.

The defect width of the preoperative CSD was the prognostic index of CSD anatomical repair effect. When the preoperative CSD width >18.85 mm, we should pay more attention to the edge of the defect during vaginal repairing.

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NCT00816881.

Remaining life is an important indicator of pavement residual effective service time and is directly related to maintenance decision-making with limited funds. This paper proposes a fast and non-destructive model to predict the remaining life of rigid PCC (Portland cement concrete) pavement, with or without asphalt overlay. Firstly, a model was constructed according to the current Chinese design specifications for concrete pavement integrating an inverse design concept. Secondly, the prediction model was applied to three typical pavement sections with 1430, 1250 and 1000 slabs, respectively. Ground penetrating radar (GPR) was utilized to determine the geometric parameters in the predictive model and the physical state of the pavement. A falling weight detector (FWD) was utilized for determination of the mechanical parameters. A more reasonable equivalent elastic modulus of foundation was back-calculated instead of using the limited model in the design specification. Thirdly, the remaining life was predicted based on the current mechanical and geometric parameters. The distributions of the remaining life of the three pavement sections was statistically analyzed. Finally, a decision-making system to inform maintenance strategy was proposed based on the remaining life and the technical condition of each slab. The results showed that the relationship between the remaining life and the mechanical parameters, geometric parameters and the physical state of the pavement was highly consistent with engineering experience. The success rate of the prediction model was as high as 96%. The proposed fast and non-destructive prediction model showed good engineering applicability and feasibility. The decision-making system was shown to be feasible in terms of economic benefits.

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