BackgroundIn locally advanced rectal cancer (LARC), preoperative short-course radiotherapy (SCRT) with delayed surgery has been shown to be as effective as long-course chemoradiotherapy, with only modest benefits. This study aimed to evaluate the efficacy and safety of preoperative SCRT combined with subsequent CAPOX (capecitabine and oxaliplatin) and the anti-PD-1 antibody camrelizumab in patients with LARC.MethodsThis was a prospective, single-arm, phase II trial. Treatment-naïve patients with histologically confirmed T3-4N0M0 or T1-4N+M0 rectal adenocarcinoma received 5×5 Gy SCRT with two subsequent 21-day cycles of CAPOX plus camrelizumab after 1 week, followed by radical surgery after 1 week. The primary endpoint was pathological complete response (pCR) rate. Biomarker analysis was performed to identify a potential predictor of pCR to treatment.ResultsFrom November 7, 2019 to September 14, 2020, 30 patients were enrolled, and 27 patients received at least one dose of CAPOX plus camrelizumab. Surgery was performed in 27 (100%) patients. The pCR (ypT0N0) rate was 48.1% (13/27), including 46.2% (12/26) for proficient mismatch repair (MMR) tumors and 100% (1/1) for deficient MMR tumors. Immune-related adverse events were all grade 1–2, with the most common being reactive cutaneous capillary endothelial proliferation (81.5%). No grade 4/5 adverse events occurred. Biomarker analysis showed patients without FGFR1–3 deletions had a better tendency for pCR.ConclusionsSCRT combined with subsequent CAPOX plus camrelizumab followed by delayed surgery showed a favorable pCR rate with good tolerance in patients with LARC, especially in the proficient MMR setting. A randomized controlled trial is ongoing to confirm these results.Trial registration numberClinicalTrials.gov identifier: NCT04231552.
Leaf surface is a multifunctional interface between a plant and its environment, which affects both ecological and biological processes. Leaf surface topography directly affects microhabitat availability and ability for deposition. In this study, atomic force microscopy (AFM) and the resuspended particulate matter method were applied to evaluate the adsorptive capacity of the leaf surface. Patterns of particulate-capturing capacities in different tree species and the effect of leaf surface features on these capacities were explored. Results indicated the following: (1) more total suspended particles (TSP) per unit leaf area were captured by coniferous tree species than by broad-leaved tree species in a particular order-i.e., Pinus tabuliformis > Pinus bungeana > Salix matsudana > Acer truncatum > Ginkgo biloba > Populus tomentosa; (2) Significant seasonal variation in particulate-capturing capacities were determined. During the observation period, the broad-leaved tree species capturing TSP and coarse particulate matter (PM 10 ) clearly exhibited a ∩-shape pattern-that is, increasing initially and later on decreasing; meanwhile, the ∩-shape pattern was not clearly shown in P. tabuliformis and P. bungeana. However, no obvious patterns in the absorption of fine particulate matter (PM 2.5 ) were found in the tested tree species; (3) The leaf surface topography, as observed by AFM and scanning electron microscopy, revealed that the broad-leaved tree exhibits a good correlation between micro-roughness of leaf surfaces and density of particles settling on leaf surfaces over time. However, the main factors affecting the adsorptive capacities of the leaves in coniferous trees are the number of stomata as well as the amount of epicuticular wax and the properties of the cuticle in different seasons.
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