The complete relative and absolute stereochemistries
have been elucidated for the ansamycin antibiotics
(+)-trienomycins A, B, and C and their potent antifungal congeners,
the (+)-mycotrienins I and II. A new species,
(+)-trienomycin F, has also been isolated and characterized. In
addition, an end-game synthetic strategy for the
trienomycins and mycotrienins has been developed.
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