This paper describes a semi-automated process, framework and tools for harvesting, assessing, improving and maintaining high-quality linked-data. The framework, known as DaCura 1 , provides dataset curators, who may not be knowledge engineers, with tools to collect and curate evolving linked data datasets that maintain quality over time. The framework encompasses a novel process, workflow and architecture. A working implementation has been produced and applied firstly to the publication of an existing social-sciences dataset, then to the harvesting and curation of a related dataset from an unstructured data-source. The framework's performance is evaluated using data quality measures that have been developed to measure existing published datasets. An analysis of the framework against these dimensions demonstrates that it addresses a broad range of real-world data quality concerns. Experimental results quantify the impact of the DaCura process and tools on data quality through an assessment framework and methodology which combines automated and human data quality controls.
Cancer
is the second leading cause of death globally, responsible for an
estimated 9.6 million deaths in
2018, and this burden continues to increase. Therefore, there is a
clear and urgent need for novel drugs with increased efficacy for
the treatment of different cancers. Previous research has demonstrated
that brevilin A (BA) exerts anticancer activity in various
cancers, including human multiple myeloma, breast cancer, lung cancer,
and colon carcinoma, suggesting the anticancer potential present in
the chemical scaffold of BA. Here, we designed and synthesized
a small library of 12 novel BA derivatives and evaluated the biological anticancer effects of
the compounds in various cancer cell lines. The results of this structure–activity
relationship study demonstrated that BA derivatives BA-9 and BA-10 possessed significantly improved
anticancer activity toward lung, colon, and breast cancer cell lines. BA-9 and BA-10 could more effectively reduce
cancer cell viability and induce DNA damage, cell-cycle arrest, and
apoptosis when compared with BA. Our findings represent
a significant step forward in the development of novel anticancer
entities.
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