AQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab-/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO.
Amblyopia is a common developmental disorder in adolescents and children. Stereoscopic loss is a symptom of amblyopia that can seriously affect the quality of patient’s life. Recent studies have shown that the push-pull perceptual learning protocol had a positive effect on stereoscopic recovery. In this study, we developed a stereoscopic training method using a polarized visualization system according to the push-pull protocol. Dichoptic stimulation for 36 anisometropic and amblyopic subjects and 33 children with normal visual acuity (VA) has been conducted. Electroencephalogram (EEG) was used to evaluate the neurophysiological changes before, during, and after stimulation. For the anisometropic and amblyopic subjects, the statistical analysis demonstrated significant differences (p<0.01) in the beta rhythm at the middle temporal and occipital lobes, while the EEG from the normal VA subjects indicated no significant changes when comparing the results before and after training. We concluded that the dichoptic training in our study can activate the middle temporal visual area and visual cortex. The EEG changes can be used to evaluate the training effects. This study also found that the beta band EEG acquired during visual stimulation at the dorsal visual stream can be potentially used for predicting acute training effect. The results facilitated the optimization of the individual training plan.
In order to evaluate refractive amblyopia suppression and understand the neural mechanism of amblyopia suppression and push-pull perception training, we recorded the EEG of refractive amblyopia children before, during, and after push-pull perception training. We compared the brain activity in different states through the steady-state visual evoked potentials (SSVEPs) response and power topography and compared them with normal children. We found that amblyopic and fellow eyes have different performances in fundamental and harmonic frequency responses. They also show different characteristics when be masked. Push-pull perception training improved the SSVEP performance of amblyopia children by reducing the SSVEP response difference between eyes and improving the intermodulation frequency response. The result of topography showed that push-pull perception reduced the alpha power of occipital and temporal lobes, which was conducive to improving binocular function. The changes of intermodulation response and occipital alpha power were significantly correlated with the clinical indicator. Thus, EEG is a potential method to measure amblyopia suppression and the efficacy of push-pull perception.
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