To cite this article: Ng WP, Liew BS, Idris Z, Rosman AK. Fluorescence-guided versus conventional surgical resection of high grade glioma: a single-centre, 7-Year, comparative effectiveness study. Results: Significant longer survival time (months) was observed in the FG group compared with the conventional group (12 months versus 8 months, P < 0.020). Even without adjuvant therapy, HGG patients from FG group survived longer than those from the conventional group (8 months versus 3 months, P = 0.006). No significant differences were seen in postoperative Karnofsky performance scale (KPS) between the groups at 6 weeks and 6 months after surgery compared to pre-operative KPS. Cox proportional hazard regression identified four independent predictors of survival: KPS > 80 (P = 0.010), histology (P < 0.001), surgical method (P < 0.001) and adjuvant therapy (P < 0.001).Conclusion: This study showed a significant clinical benefit for HGG patients in terms of overall survival using FG surgery as it did not result in worsening of post-operative function outcome when compared with the conventional surgical method. We advocate a further multicentered, randomised controlled trial to support these findings before FG surgery can be implemented as a standard surgical adjunct in local practice for the benefit of HGG patients.

Epidermoid cysts are rare, benign congenital tumours of ectodermal origin which typically present between the third to fifth decade. These tumours comprise approximately 0.2-1.8% of all intracranial tumours. Though these pearly tumours are potentially curable, subtotal resection may lead to catastrophic complications such as recurrence, granulomatous meningitis and carcinomatous degeneration of cyst wall. We herein report the case of a 36-year-old man who presented with an unusual mixed density posterior fossa epidermoid cyst on imaging studies. Total removal not only cures both tumour and seizure attack in this case but also preserves patient’s neurological function.