A prospective, randomized, double-masked and placebo-controlled study was performed to compare the effects of a single 5-minute intraoperative exposure to aclacinomycin (AMC) 0.4 mg/ml or 0.8 mg/ml with control eyes treated with saline solution on the success of glaucoma filtration surgery in 26 rabbits. Intraocular pressure (IOP), bleb survival, fistula patency and complications were evaluated. The results showed that IOP in the eyes treated with AMC was significantly lower than that in the control eyes from days 5-40 in the 0.4 mg/ml group and from days 5-20 in the 0.8 mg/ml group. The bleb survival lasted significantly longer in the two treated groups than in the control group and in the AMC 0.4 mg/ml group than in the AMC 0.8 mg/ml group. At 40 days, the rate of sclera fistula occlusion was 0% in the AMC 0.4 mg/ml eyes, 43.8% in the AMC 0.8 mg/ml eyes, and 100% in the control eyes. Significant complications, such as anterior chamber inflammation, hyphema, moderate and severe corneal haze, dense corneal neovascularization and mild cataract occurred only in the eyes treated with AMC 0.8 mg/ml. The results indicated that intraocular treatment with AMC at a dose of 0.4 mg/ml had a markedly beneficial effect on IOP, bleb appearance and fistula patency after experimental filtration surgery in rabbits.
Usually, when there is no glare light source, the light reflected by the target is received by the human eye and then imaged on its retina. The observer can clearly see the target object, and the human eye can correctly judge the movement speed and direction of the target. However, when the glare light source exists, the glare light is scattered to form a light curtain, which is superimposed on the retina. If the scattered light is not too strong, it will not cause discomfort to the human eye, but it reduces the observer's perception of the target object. The visual sense reduces the contrast between the target object and the environment in the human eye, and reduces the human visual response speed. Incoherent directional beam glare interferes with the visual function of normal eyes through instantaneous strong light stimulation, causing temporary loss or decline of visual function, as well as image retention, discomfort, and avoidance responses such as blinking, closing eyes, and turning heads. Based on the mechanism of glare effect, the influencing factors of glare were analyzed, and the influence of incoherent directional beams on human vision was studied from the aspects of light source brightness, irradiation time, flicker frequency, etc. The research results provide data support for the design and use of incoherent glare weapons, and lay the foundation for the application of incoherent directional beam glare weapons in public security fields such as border defense and denial, maritime expulsion, and anti-terrorism and stability maintenance.
Background This study investigated the diagnostic and therapeutic experience, including conservative, endoscopic and surgical methods, of chronic suppurative spondylitis. Methods A total of 39 patients were included in the imageological, laboratory, and pathological examinations. The patients underwent conservative treatment or operation according to their respective conditions. We used erythrocyte sedimentation rate (ESR) and c-reactive proteins (CRP) to evaluate the state of the illness, visual analogue scales (VAS) to assess lower back and lower limb pain, and the oswestry dysfunction index (ODI) to assess the degree of functional disability. All patients were followed up for 12–36 months. Results Two patients were treated conservatively with antibiotics for 6–8 weeks, while 34 patients underwent different open surgeries, including two cases who underwent second stage surgery. Endoscopic surgery was operated on 3 patients under acute inflammatory stage. All patients' body temperature, VAS score, ESR, and CRP decreased significantly (P < 0.05). Imaging showed that lesions were stationary and that bone fusion occurred 8–14 months after surgery, with an average of 10.00 ± 0.92 months. Conclusions Clinicians should acquire a detailed medical history and evaluate the laboratory and imaging results comprehensively to select an appropriate treatment plan. Treatment, including the choosing of an adequate surgical method, should be based on the purpose of the operation and the patient's general condition.
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