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Several studies suggest that public trust in government in China remains high and without any trend of decline despite the fact that public trust in government has declined dramatically in developed countries. This article analyses public trust in government in contemporary urban China with a comprehensive representative survey and tests the factors associated with public trust in government. Trust in government in China is found to be much lower than previous studies have indicated. Furthermore, the variables of citizen satisfaction with the quality of public services, general democracy, participation in government and the transparency of government are positively associated with public trust in government in China at both the city and central level. In addition, this research also finds that citizens who are younger, more highly educated and well-paid have a lower probability of trust in government in China. These findings suggest that maintaining political trust will be a challenge for the Chinese government. Points for practitioners The findings in this study suggest that public managers and policymakers in China should pay full attention to the challenge posed by maintaining public trust in government, and need to consider formulating specific and feasible measures to enhance public trust based on the determinants of public trust in government. Moreover, in terms of the fact that the determinants that make public trust in government decline in developed countries also affect public trust in government in China, such public managers and policymakers need to strengthen communication with developed countries to improve the handling of the common challenge of maintaining public trust in government.

pH-sensitive chemical exchange saturation transfer (CEST) MRI holds great promise for in vivo applications. However, CEST effect depends on not only exchange rate and hence pH, but also on the contrast agent concentration, which must be determined independently for pH quantification. Ratiometric CEST MRI normalizes the concentration effect by comparing CEST measurements of multiple labile protons to simplify pH determination. Iopamidol, a commonly used X-Ray contrast agent, has been explored as a ratiometric CEST agent for imaging pH. However, iopamidol CEST properties have not been solved, determination of which is important for optimization and quantification of iopamidol pH imaging. Our study numerically solved iopamidol multi-site pH-dependent chemical exchange properties. We found that iopamidol CEST MRI is suitable for measuring pH between 6 and 7.5 despite that T1 and T2 measurements varied substantially with pH and concentration. The pH MRI precision decreased with pH and concentration. The standard deviation of pH determined from MRI was 0.2 and 0.4 pH unit for 40 and 20 mM iopamidol solution of pH 6, and it improved to be less than 0.1 unit for pH above 7. Moreover, we determined base-catalyzed chemical exchange for 2-hydrooxypropanamido (ksw=1.2*10pH−4.1) and amide (ksw=1.2*10pH−4.6) protons that are statistically different from each other (P<0.01, ANCOVA), understanding of which should help guide in vivo translation of iopamidol pH imaging.

2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2018.