Prematurity and low birth weight are some of the causes of neonatal death and significant health problem. This study aimed to determine the influence of gestational age and birth weight on neonatal mortality at the Al Islam Hospital Bandung in 2015–2019. It was a case-control retrospective observational analysis using medical records of the Al Islam Bandung Hospital from January 1, 2015, to December 31, 2019. The inclusion criteria for infants were born alive. Exclusion criteria had severe congenital abnormalities and gestational age <26 weeks. The chi-square test evaluated the univariate comparison test of risk factors between 2 groups. Multiple logistic regression to assess neonatal mortality's predictive factors and the percentage contribution of the influence was calculated (Nagelkerke’s R2 analysis). The number of infants enrolled in 2015–2019 was 6,791 neonates, and who died was 56 neonates (0.82%). In premature infants and low birth weight there was a very significant relationship with neonatal mortality, respectively p=0.000 (p<0.05) OR=30.397 (CI=16.506–55.976), and p=0.000 (p<0.05) OR=41.206 (CI=18.611–91.233). In the multiple logistic regression test, p=0.000 (p<0.05), with a Nagelkerke’s R2 value of 0.344 or 34.4%. This presence that gestational age and birth weight significantly affects neonatal mortality, either partially or simultaneously. The percentage contribution of the influence of gestational age and birth weight to neonatal mortality was 34.4%. PENGARUH USIA GESTASI DAN BERAT BADAN LAHIR TERHADAP KEMATIAN NEONATUSPrematuritas dan berat badan lahir rendah merupakan beberapa penyebab kematian neonatus dan masalah kesehatan yang signifikan. Penelitian ini bertujuan mengetahui pengaruh usia gestasi dan berat badan lahir terhadap kematian neonatus di RS Al Islam Bandung tahun 2015–2019. Penelitian ini merupakan penelitian observasional retrospektif kasus kontrol menggunakan data rekam medis RS Al Islam Bandung periode 1 Januari 2015 hingga 31 Desember 2019. Kriteria inklusi bayi lahir hidup. Kriteria eksklusi bayi dengan kelainan kongenital berat dan usia gestasi <26 minggu. Uji chi-square mengevaluasi perbandingan univariat faktor risiko antara 2 grup. Regresi logistik multipel untuk mengevaluasi faktor prediktif kematian neonatus dan persentase kontribusi pengaruh dihitung (Analisis R2 Nagelkerke). Jumlah bayi yang dirawat tahun 2015–2019 sebanyak 6.791 dan yang meninggal sebanyak 56 (0,82%). Pada bayi lahir prematur dan berat badan lahir rendah terdapat hubungan sangat bermakna terhadap kematian neonatus, berturut-turut p=0,000 (p<0,05) OR=30,397 (CI=16,506–55,976) dan p=0,000 (p<0,05) OR=41,206 (CI=18,611–91,233). Pada uji regresi logistik multipel, p=0,000 (p<0,05) dengan nilai R2 Nagelkerke sebesar 0,344 atau 34,4%. Usia gestasi dan berat badan lahir berpengaruh bermakna terhadap kematian neonatus, baik secara parsial maupun simultan. Persentase sumbangan pengaruh usia gestasi dan berat badan lahir terhadap kematian neonatus sebesar 34,4%.
Skabies merupakan penyakit kulit oleh tungau Sarcoptes scabiei, penyakit ketiga paling sering di Indonesia. Pengobatan lini pertama yang direkomendasikan adalah krim permetrin 5% dan pengobatan lain menurut pusat pengendalian dan pencegahan penyakit, adalah ivermektin oral dengan dosis 200 mcg/kgBB, dua dosis 14 hari terpisah.Metode yang digunakan adalah systematc review dengan mengevaluasi artikel publikasi ilmiah dengan desain penelitian randomized control trial sesuai dengan kriteria inklusi, dengan intervensi pemberian permetrin dan pembanding ivermektin, dilakukan skrining menggunakan kriteria kelayakan. Hasil yang didapat, 3 jurnal mengenai efektivitas ivermektin dan permetrin yaitu, dosis tunggal ivermektin memberikan tingkat kesembuhan pada interval 2 minggu. Terapi dua aplikasi permetrin dengan interval satu minggu memiliki nilai yang efektif yang tinggi pada pasien. Empat jurnal menyatakan bahwa permetrin lebih unggul dalam penatalaksanaan skabies. Permetrin 5% topikal menunjukkan perbaikan lebih cepat pada minggu pertama follow up. Satu jurnal menyatakan bahwa aplikasi ivermektin sama efektifnya dengan dua aplikasi krim permetrin 2,5% follow-up 2 minggu. Setelah mengulangi pengobatan, ivermektin sama efektifnya dengan krim permetrin 2,5%. Simpulan pemberian keduanya dapat mengobati skabies. Aplikasi permetrin dua kali dengan interval satu minggu dinilai lebih efektif daripada ivermektin dosis tunggal dan pasien sembuh lebih awal. Dua dosis ivermektin sama efektifnya dengan aplikasi tunggal permetrin. Systematic Review: The Effectiveness of Therapy Comparison between Ivermectin with permetrin Therapy in Scabies TreatmentScabies, a skin disease caused by the mite Sarcoptes scabiei, is the third most common disease in Indonesia. The recommended first-line treatment is 5% permetrin cream and another treatment according to the Centers for Disease Control and Prevention, is oral ivermectin at a dose of 200 mcg/kg body weight, two doses 14 days apart. The method used is a systematic review with a randomized control trial research design in accordance with the inclusion criteria and screening using the eligibility criteria. The results obtained: 3 journals regarding the effectiveness of ivermectin and permetrin which stated that a single dose of ivermectin provided a cure rate at 2 week intervals, two applications of permetrin at one-week intervals have high effective values; 4 journals stated that topical 5% permetrin showed faster improvement in the first week of follow-up; 1 journal stated that ivermectin applications were as effective as two applications of 2.5% permetrin cream at 2 weeks follow-up. After repeating the treatment, ivermectin is as effective as 2.5% permetrin cream. The conclusion is that giving both can cure scabies. Twice application of permetrin at one-week intervals was considered more effective than single dose ivermectin and the patient recovered earlier. Two doses of ivermectin are as effective as a single application of permetrin.
Introduction: Congenital syphilis involves any organs with various symptoms, including neurological signs. Neurosyphilis is a severe syphilis complication that can develop at any stage of illness. Case presentation: A 2,520 g male infant was spontaneously born at term from an untreated syphilis mother. Physical examination revealed decreased consciousness, respiratory distress, seizure, but without neurologic abnormality sign. The serum and cerebrospinal fluid Venereal Disease Research Laboratory and Treponemal Pallidum Hemagglutination Assay TPHA tests titters were 1:16 and 1:1,280, respectively. The diagnosis at admission was respiratory failure and neonatal sepsis. The infant was mechanically ventilated and treated with early management of sepsis. Blood culture was sterile later on. Then, the infant was administered intramuscular benzathine penicillin G (50,000 units/kg/dose) for a total of three weeks. The infant's condition was improved during the treatment. Conclusions: There are many challenges associated with screening and monitoring neurosyphilis in congenital syphilis. Congenital syphilis presenting as sepsis is easily misdiagnosed as bacterial sepsis.
Abstract. Prematurity can affect brain development processes, resulting in behavioral and cognitive changes in speech and language development. Speech delay are the most common developmental disorder in children and can be detected at the age of two to five years, which is the golden period of child development. The aim of this study was to analyze the relationship between prematurity and speech delay in children aged two to five years. This study uses a scoping review by searching for articles from PubMed, Science Direct, and SpringerLink. In the initial search, 1,229 articles were found. There were 479 articles that met the inclusion criteria, and 750 articles were excluded. The final results of the feasibility test and critical review based on PICOS and the eligibility criteria were obtained for six articles. This research was carried out between February and December of 2021. The results of the study and analysis of five articles stated that there was a correlation in children with a history of preterm birth, either from the category of moderate-to-late preterm (birth at 32 to 36 weeks) or very preterm (birth at 25 to 31 weeks), who are at risk for language performance, consisting of a less expressive vocabulary than children with a history of full-term birth. Based on this study, it can be concluded that prematurity can increase the risk of speech delay in children aged two to five years. Abstrak. Kelahiran prematur dapat mempengaruhi proses perkembangan otak yang mengakibatkan perubahan perilaku dan kognitif dalam perkembangan ucapan dan bahasa. Keterlambatan bicara merupakan gangguan perkembangan yang paling umum pada anak-anak dan dapat dideteksi pada usia dua sampai lima tahun yang merupakan periode emas perkembangan anak. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara prematuritas dengan keterlambatan bicara pada anak usia dua sampai lima tahun. Penelitian ini menggunakan scoping review, dengan pencarian artikel yang berasal dari database PubMed, Science Direct, dan Springer Link. Pada pencarian awal didapatkan sebanyak 1.229 artikel. Terdapat 479 artikel yang sesuai dengan kriteria inklusi, dan terdapat 750 artikel yang dieksklusi. Hasil akhir uji kelayakan dan telaah kritis berdasarkan PICOS dan kriteria kelayakan didapatkan lima artikel. Penelitian ini dilakukan pada periode Februari sampai dengan Desember 2021. Hasil telaah dan analisis dari lima artikel menyatakan terdapat kolerasi pada anak prematur dari kategori moderate to late preterm (kelahiran pada 32 sampai 36 minggu) dan very preterm (kelahiran pada 25 sampai 31 minggu) memiliki risiko mengalami keterlambatan kinerja bahasa yang terdiri dari kosakata yang kurang ekspresif dibandingkan anak dengan riwayat lahir cukup bulan. Pada penelitian ini dapat disimpulkan bahwa prematuritas dapat meningkatkan risiko terjadinya keterlambatan bicara pada anak usia dua sampai lima tahun.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.