Chondromyxoid fibroma of the skull base is extremely uncommon. Sometimes involvement of the nasal cavity may occur and the patients may present with nasal symptoms. The biological behaviour of this tumour has not been well studied, primarily because of the limited number of reported cases and the short duration of followup. We report a histologically confirmed case of chondromyxoid fibroma of the skull base that recurred repeatedly over a 10-year period after the initial operation. Histologically it showed identical morphology to the original tumour with no evidence of histological progression or dedifferentiation. Ultrastructurally, the spindle tumour cells in the fibromyxoid area showed dual chondroblastic and fibroblastic differentiation, suggesting that these spindle fibroblastic cells and the better differentiated chondroid cells were of the same cell type with different histological morphology.
Over a 3-year period, four cases o f maxillary osteoradionecrosis were diagnosed in patients undergoing radiotherapy for nasopharyngeal carcinoma at the Queen Mary Hospital, Hong Kong, giving an estimated incidence of 0.8%. Patients with this complication presented after a mean period of 34 months post-radiotherapy. Risk factors that were identified were dental problems, and more than one full course o f radical radiotherapy. Serial CT scans in the axial and coronal planes were useful in demonstrating the development, extent and features o f maxillary osteoradionecrosis such as bony sclerosis, the destruction of maxillary antral walls and adjacent bony structures, and in excluding recurrent tumour.
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