The induction of TIGR/MYOC by DEX is HTM-specific, whereas its secretory and glycosylation characteristics are ubiquitous. The known functions of HTM-DEX-specific genes reveal the presence of protective and damaging mechanisms for regulation of IOP during DEX treatment. Besides TIGR/MYOC, other HTM-DEX-specific genes may be good candidates for linkage to glaucoma.
Purpose
To evaluate the safety and effect of bevacizumab pretreatment on incidence of recurrent vitreous hemorrhage and visual acuity after vitrectomy for proliferative diabetic retinopathy (PDR).
Study Design
Consecutive, retrospective, comparative cohort study
Methods
Patients undergoing vitrectomy from September 2006 through November 2007 at the Emory Eye Center for complications of PDR were identified and reviewed. A total of 33 eyes pretreated with bevacizumab and 104 eyes untreated were followed for postoperative vitreous hemorrhage and final visual acuity.
Results
Patients in the bevacizumab group were significantly younger than the untreated group (average age 46.4 vs. 58.4) and were more likely to have 20 ga instrumentation (58% vs. 36%). An average of 9.6 days passed between injection and surgery. Early (4-6 weeks) rebleed rates were 15% vs. 13% in the bevacizumab and untreated groups, respectively, and not statistically different. Preoperative (7/200 vs. CF 4′), 1 month postoperative (20/200-3 vs. 20/150), and 3 month postoperative visual acuity (20/100-3 vs. 20/100+2) were not statistically different between groups. No statistical difference was found in rebleed rates with regard to gauge of vitrectomy.
Conclusions
Bevacizumab pretreatment for diabetic vitrectomy was not associated with any observed complications, but may not influence rates of postoperative vitreous hemorrhage or final visual acuity. The overall incidence of postoperative early vitreous hemorrhage in this series was 13% and appears lower than historically reported rates.
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