This research was concerned with a study of the relationship between sorbitol dehydrogenase and hepatitis disease. Blood samples have been drawn from (35) patients with hepatitis and (28) blood samples of healthy as control group ages ranges from (40-65) years. Patients were collected from Al-Salam Hospital in Mosul City under the supervision of specialists Live in Mosul city. Sorbitol dehydrogenase, total serum bilirubin, protein, albumin, globulin and alanine aminotransferase sGPT were measured in blood of these patients. The results showed a significant increase in sorbitol dehydrogenase, sGPT, bilirubin, total serum protein, albumin and globulin levels compared with the control group. There was also study of the relationship between (SDH) activity and the studied parameters in patient group and finding that there are liner correlation coefficient. the results indicated that, there was a positive significant correlation between the activity of enzyme and each of the total protein, albumin, globulin, sGPT, and bilirubin and negative significant corolation between SDH and globulin.
This research includes a biochemical study of sorbitol dehydrogenase (SDH) in the serum of the control and patient with diabetes mellitus. Their ages ranged between (8-65year). It has been shown that the mean value of (SDH) activity is (0.015± 0.010) of the control group and)0.516±0917) of the patient groups .The result shown that significant increase in activiyof (SDH) patient groups and for each sexes when compared with control groups .There was a study of the relationship between (SDH) activity and clinical variables of the control and patient groups by finding the linear correlation was studied. Moreover , there was positive significant correlation between the activity of enzyme and each of glucose , total protein , albumin , globulin , in control and patient groups. Inverse significant correlation between the activity and Ca++ in control and patient groups .
This research includes study of the effects of general anesthesia on lipid peroxide formation and some antioxidant system in serum of patients with appendix surgery. Forty seven patients under general anesthesia with age range of 15-45 years living in Mosul city were selected. The level of serum malondialdehyde (MDA), reduced form of glutathione (GSH), superoxide dismutase (SOD), uric acid, albumin and ceruloplasmin were measured. The results showed a significant increased in MDA level (as an index of lipid peroxidation) in patients under pentothal anesthesia in comparison with preoperative samples. On the other hand, patients under general anesthesia had decreased GSH concentration, SOD activity, uric acid, albumin and ceruloplasmin concentration when compared with preoperative samples.
To study the effect of iron overload due to continuous blood transfusions on peroxidation products, such as malondialdehyde (MDA) and peroxynitrite, with evaluation of some antioxidants like, glutathione (GSH), superoxide dismutase (SOD), vitamin A, vitamin C, vitamine E, Ceruloplasmin, uric acid and albumin in thalassemia patients. Forty patients with thalassemia major, aged 5 to 15 years, were carried out in Abn-Alatheer Teaching Hospital in Mosul city, during the period from October 2007 to April 2008. They were on Chelation therapy with desferÂrioxamine. They were divided into two groups, the first one without iron overload (90,97±12.92), and the second one with iron overload (157.75±7.57). All the patients were received whole blood. Blood samples were collected before and after blood transfusion. The results showed that there were significant increase in MDA and peroxynitrite in patients with iron overload five days before and after blood transfusion in compared with groups having normal iron level. On the other hand, glutathione, superoxide dismutase activity, Vitamin A, vitamin C, vitamin E, albumin and ceruloplasmin were significantly decreased whereas, uric acid was increased significantly. It is concluded that, Iron over load due to continuous blood transfusion in thalassemia causes increase in oxidative tissue damage with a changes in antioxidants status. Key Words: Beta-thalassemia, lipid peroxidation, antioxidants, Malondialdehyde, Iron
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