No abstract

No abstract

A new meroterpenoid, named tatenoic acid (1), was isolated from the fungus Neosartorya tatenoi KKU-2NK23, together with five known compounds, aszonapyrones A and B (2 and 3), aszonalenin (4), ergosterol (5) and D-mannitol (6). Their structures were established on the basis of spectroscopic methods. Aszonapyrones A (2) exhibited antimalarial activity against Plasmodium falciparum, and it also exhibited cytotoxicity against two cancer cell lines, NCI-H187 and KB.

 Abstract-The aim of the present study was to identify ascomycetous fungi (Neosartorya spp.) and examined the antibacterial activities of crude mycelium extracted by ethyl acetate from these fungal genera. Among 10 ascomycetous fungal isolates, Neosartorya sp., were screened from soil and showed a broader antimicrobial spectrum than the other. Especially, fungal strain KKU-1NK1 showed strongly antibacterial activities. This fungal strain was belonging to Neosartorya spinosa which was identified using 5.8S rRNA gene sequencing analysis. The results revealed that the growth of clinical isolates of gram-positive pathogenic bacteria (Methicillin-resistant Staphylococcus aureus DMST 20654, Staphylococcus aureus ATCC 25923, Staphylococcus saprophyticus ATCC 15305, Streptococcus pneumonia DMST 15319 and Bacillus subtilis ATCC 6633) was well inhibited by crude mycelial extracted from N. spinosa KKU-1NK1 at concentrations values of 10 mg/ml. Moreover, the effects of submerge culture media variation on mycelia growth which affected to total production of bioactive compounds and antibacterial activity by N. spinosa KKU-1NK1 was observed.