Aims: Genetic variations in DNA repair genes may impact repair functions, DNA damage, and breast cancer risk. This study is aimed to assess the associations of genetic polymorphisms in excision repair cross-complementing group 2 (ERCC2) with the risk of developing breast cancer. Materials and Methods: In total, 101 histopathologically confirmed breast cancer cases and 101 age/region-matched healthy controls were genotyped for rs3916840, rs1799793, and rs238416 in ERCC2 by polymerase chain reaction-restriction fragment length polymorphism. Results: The rs238416 heterozygous GA genotype combined with the rs238416 genotypes (GA + AA) showed a significant association with breast cancer susceptibility (corrected p < 0.01, odds ratio [OR] = 0.29, 95% confidence interval [CI] = 0.15-0.54; corrected p < 0.01, OR = 0.31, 95% CI = 0.17-0.56, respectively). The rs238416 GA genotype carriers had a decreased risk of breast cancer. However, we observed no significant association between the rs3916840 and rs1799793 polymorphisms in ERCC2 and breast cancer risk. Moreover, haplotype analysis showed that the ACG haplotype was associated with a significantly decreased risk of breast cancer, whereas the GCG haplotype was associated with a significantly increased risk of breast cancer (corrected p = 0.004 and p = 0.002, respectively). Multifactor dimensionality reduction analysis demonstrated that the interactions between rs3916840 and rs238416 were significantly synergistic. Conclusion: To the best of our knowledge, this study is the first to demonstrate that the rs238416 heterozygous genotype likely has a higher DNA repair capacity and, thus, can be protective against breast cancer in Chinese Han women.
The weakly cemented sandstone is the host rock in the Cretaceous and Jurassic strata with low intensity, high water-bearing capacity and sensitivity to disturbance. In order to investigate the influence of temperature and confining pressure on the permeability of weakly cemented sandstone, scanning electron microscope were used to characterize microstructure of the particles, a series of triaxial creep tests were performed on coarse sandstone, medium sandstone and fine sandstone separately, and the effect of particle size on the permeability of sandstone was also analyzed. The results indicate that the increase of confining pressure led to the plastic deformation between the rock particles, that permeability was irreversible as the confining pressure changed, and that the permeability reduction rate of coarse sandstone was lower than that of fine sandstone. The sensitivity of weakly cemented sandstone to temperature and confining pressure increased as the sizes of the particles decreased, and the effect on permeability was more obvious.
SHRIMP U-Pb zircon analyses for a gabbro sample from the Garzê ophiolite block yielded a mean 206 Pb/ 238 U age of 292±4 Ma, which indicated that the spreading time of the Garzê-Litang Tethys was most likely at the earliest Permian. Combined with previous studies, we suggest that the opening of the Tethys in southwest China was derived from breakup of the East Gondwanaland in the late Paleozoic.
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