Infection with recombinant avian leukosis virus (ALV) has previously been linked to malignancies and immunosuppression. However, the processes behind recombinant ALV's unique pathophysiology are poorly understood. The study aims to investigate the gene expression patterns of a recombinant ALV isolate GX14FF03 infected chicken broblast cells (CEFs) and used the RNA-Sequence technique to undertake a complete analysis of the mRNAs transcriped. As a consequence, a total of 907 signi cant differentially expressed genes (SDEGs) were identi ed. Among these SDEGs, the most signi cantly up-regulated gene was interleukin 8-like 1 (IL8L1), while the most signi cantly down-regulated gene was broblast growth factor 16 (FGF16). The 907 SDGEs were highly enriched (p < 0.05) for 252 Gene Ontology (GO) terms, including 197 BP, 3 CC, and 52 MF. According to the KEGG data analysis, SDEGs are implicated in eight signi cant pathways (p < 0.05). Furthermore, PPI network analyses revealed that IL8L1 interacts with 17 genes. These ndings provide light on the molecular mechanisms of the recombinant ALV infection by explaining the mRNA expression pro le in CEFs infected with GX14FF03 virus.
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