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A series of Ni-based catalysts supported on different MgO supports were investigated for hydrogen production via steam reforming (SR) of acetic acid (HAc). Three types of NiO and MgO solid solutions were prepared by co-precipitation of Ni(NO 3 ) 2 and Mg(NO 3 ) 2 , impregnation of Ni(NO 3 ) 2 on MgO, and impregnation of Ni(NO 3 ) 2 on mesoporous MgO (denoted as MgO-m), respectively. The Ni-based catalysts were prepared by reducing these solid solutions at 650 °C in 10% H 2 /Ar. N 2 adsorption results showed that the Brunauer−Emmett−Teller (BET) surface area of NiO/MgO-m solid solution was 3.0 and 2.3 times that of NiO−MgO and NiO/MgO solid solutions, respectively. The Ni/MgO-m catalyst showed the best catalytic performance, and the H 2 yield can be enhanced by ∼160% by using the Ni/MgO-m catalyst. Ni/MgO-m kept its high activity up to 20 h of reaction. Thermogravimetry (TG) results indicated that no significant change was observed for the amount of carbon deposits on used Ni/MgO-m after 3 h on stream. Two kind of carbon species were observed on used Ni/MgO-m in the temperature-programmed oxidation (TPO) test.

Aims:Stroke is a complicated neurological disease and the second leading cause of death in the world. We aimed to investigate the association between CYP24A1 genetic polymorphisms and ischemic stroke risk. Methods:In this case-control study, four single-nucleotide polymorphisms of CYP24A1 were selected and genotyped by MassARRAY platform in Chinese Han population. Odds ratios and 95% confidence intervals were calculated via logistic regression analysis with adjustment in genetic models. Results:Our results indicated that CYP24A1 variant (rs1570669) was associated with the decreased risk of ischemic stroke (OR = 0.60, p < .001). Stratification analysis showed that the rs6068816 could enhance the ischemic stroke risk by 1.64 times (OR = 1.64, p = .028), while rs1570669 played protective role (OR = 0.63, p = .044) in age >64 years. The rs2762934 had an increased ischemic stroke susceptibility (OR = 1.62, p = .033); however, rs1570669 might reduce stroke risk (OR = 0.61, p = .015) in age ≤64 years. The rs1570669 depressed ischemic stroke susceptibility both in female and male patients (OR = 0.46, p = .002; OR = 0.69, p = .033, respectively), and rs2296241 would weaken the risk in male (OR = 0.63, p = .012). The rs1570669 was associated with decreased risk of ischemic stroke with hypertension (OR = 0.56, p = .042). Conclusion:Our study gave the evidences that CYP24A1 genetic polymorphisms were significantly associated with ischemic stroke patients, which would provide useful information of assessment or possible diagnostic markers for ischemic stroke. K E Y W O R D SCYP24A1, genetic polymorphisms, ischemic stroke

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The catalytic activity of 8.8 wt% Ni/MgO-AN prepared from alcogel derived MgO was studied for the dry reforming of methane under high pressure (1.5 MPa). The catalyst showed a self-stabilization process during the reaction that lasted for 50 h, in which the catalytic activity decreased with increasing the reaction time on stream (TOS) up to 12 h, and then became stabilized thereafter. The activity decline during the initial 12 h of the reaction was found closely related to an increase in the amount of carbon deposits on the catalyst, which also became stabilized after the catalyst had served the reaction for 12 h. Comprehensive characterizations of the coked catalyst with Temprature programmed hydrogenation (TPH), X-ray photoelectron spectroscopy (XPS) and X-ray diffractometer (XRD) techniques revealed two kinds of carbon deposits (a-carbon and b-carbon) on the used catalyst. The a-carbon deposits were found to be produced from CH 4 decomposition while the b-carbon deposits from CO disproportionation. It was revealed that the accumulation of b-carbon deposits was a key cause for the activity decline and the self-stabilized catalysis during the initial 12 h of the high-pressure reaction. Moreover, it was also observed that an unavoidable sintering of metallic Ni particles from 6.5 to 11 nm, which happened within the very first hour of the reaction, was not directly related to the catalyst stability.

Background: The present study aimed to investigate the roles of insulin related gene IGF2BP2, HMG20A, and HNF1B variants in the susceptibility of Type 2 diabetes mellitus (T2DM), and to identify their association with age, gender, BMI, and smoking and alcohol drinking behavior among the Han Chinese population. Methods: About 508 patients with T2DM and 503 healthy controls were enrolled. Rs11927381 and rs7640539 in IGF2BP2, rs7178572 in HMG20A, rs4430796, and rs11651052 in HNF1B were genotyped by using the Agena MassARRAY. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Results: We found that HMG20A rs7178572 (OR = 1.25, P = 0.015) and HNF1B rs11651052 (OR = 1.26, P = 0.019) increased the risk of T2DM. Rs7178572, rs4430796, and rs11651052 might be related to the higher T2DM susceptibility not only by itself but also by interacting with age, gender smoking, and alcohol drinking. Rs11927381 also conferred the higher T2DM susceptibility at age ≤ 59 years. Besides, rs7178572-AA (P = 0.032) genotype and rs11651052 GG (P = 0.018) genotype were related to higher glycated hemoglobin and insulin level, respectively. Conclusion: Specifically, we first found that rs11927381, rs7640539, and rs11651052 were associated with risk of T2DM among the Han Chinese population. We also provide evidence that age, gender, BMI, smoking, and drinking status have an interactive effect with these variants on T2DM susceptibility.

Catalytic activity of Ni/MgO-AN prepared from alcogel derived MgO was studied for the dry reforming of methane under atmospheric as well as high pressure (1.5 MPa). Different catalytic performances are observed in the atmospheric and high-pressure reactions; while the catalyst was highly active and extremely stable under atmospheric pressure it shows a self-stabilization process under high pressure. The self-stabilization process was characterized initially by a decrease in deactivation rate with increasing the reaction time-on-stream (TOS) up to ca. 12 h and then by a thereafter stabilization during the reaction. Characterizations of the coked catalyst with TPO, TEM, SEM, TPH and XRD techniques detected very little carbon deposits (ca. 0.2 wt% of the catalyst charge) on the used catalyst under atmospheric pressure. In contrast, large amount of whisker carbon deposit (ca. 100 wt% of the catalyst charge) were formed on the used catalyst under high pressure. In the high-pressure reaction, the activity decline during the initial stage was closely related to the amount of carbon deposits on the catalyst, which also became stabilized after the catalyst had served the reaction for ca. 12 h. The carbon deposits on the used catalyst in the high-pressure reaction contained two different components (a-carbon and b-carbon) while the carbon deposits in the atmospheric pressure reaction were in the form of a-carbon. No notable sintering of metallic nickel was detected by XRD on the used catalyst in the reaction under atmospheric pressure whereas unavoidable sintering of metallic Ni particles happened within the very first hours of the high-pressure reaction.