Object oriented manufacturing resource modelling for adaptive process planning YUYUN ZHANG{*, SHAW C. FENG{, XIANKUI WANG}, WENSHENG TIAN} and RUIRONG WU} Computer-aided process planning (CAPP) performs an important function, integrating product design with production, but has not kept pace with CAD/CAM developments. More and more attention has been paid to CAPP automation, intelligence and CAD/CAPP/CAM integration, and a plethora of prototype systems has been developed. However, CAPP applications are less than satisfactory. With the objective of improving CAPP usability and adaptability, this paper proposes object-oriented manufacturing resources modelling (OOMRM) and agent-based process planning (AAPP). The OOMRM exceeds the framework of traditional manufacturing resource databases. It describes manufacturing resources capability and capacity in an object-oriented manner, which intends to encapsulate manufacturing system knowledge and the methods of using the knowledge. Based on the OOMRM, an AAPP prototype is implemented as a man± machine integrated process planning platform. It will support an experienced manufacturing engineer in mapping out a more reasonable and¯exible machining process.
Accumulating evidence has demonstrated that the aberrant expression of microRNAs (miRs or miRNAs) may contribute to the initiation and progression of various types of human cancer and may also constitute biomarkers for cancer diagnosis and therapy. However, the specific function of miR‐9 in hepatocellular carcinoma (HCC) remains unclear, and the mechanisms that underlie HCC are incompletely understood. Here, we report that miR‐9 expression was significantly decreased in clinical tumor tissue samples, as well as in a cohort of HCC cell lines. In addition, it was demonstrated that overexpression of miR‐9 suppressed the proliferative and migratory capacity of HCC cells and impaired cell cycle progression. Furthermore, high mobility group AT‐hook 2 (HMGA2) was verified as a downstream target gene of miR‐9 using a luciferase reporter assay. Quantitative RT‐PCR and western blotting implicated HMGA2 in the miR‐9‐mediated reduction of HCC cell growth. In vivo, transfection with miR‐9 mimics down‐regulated the expression of HMGA2, thus leading to a dramatic reduction in tumor growth in a mouse xenograft model. These results suggest that miR‐9 may exert critical antitumor effects on HCC by directly targeting HMGA2, and the miR9/HMGA2 signaling pathway may be of use for the diagnosis and prognosis of patients with HCC.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.