This meta-analysis showed that tuberculosis patients with slow acetylators had a higher risk of ATLI than other acetylators. Screening of patients for the NAT2 genetic polymorphisms will be useful for the clinical prediction and prevention of ATLI.

Although most high-risk neuroblastomas are responsive to chemotherapy, relapse is common and long-term survival is less than 40%, underscoring the need for more effective treatments. We evaluated the responsiveness of 12 neuroblastoma cell lines to the Δγ134.5 attenuated oncolytic HSV, Seprehvir (HSV1716), which is currently used in pediatric phase I trials. We found that entry of Seprehvir in neuroblastoma cells is independent of the expression of nectin-1 and the sum of all four known major HSV entry receptors. We observed varying levels of sensitivity and permissivity to Seprehvir, suggesting that the cellular anti-viral response, not virus entry, is the key determinant of efficacy with this virus. In vivo, we found significant anti-tumor efficacy following Seprehvir treatment, which ranged from 6/10 complete responses in the CHP-134 model to a mild prolonged median survival in the SK-N-AS model. Taken together, these data suggest that anti-tumor efficacy cannot be solely predicted based on in vitro response. Whether or not this discordance holds true for other viruses or tumor types is unknown. Our results also suggest that profiling the expression of known viral entry receptors on neuroblastoma cells may not be entirely predictive of their susceptibility to Seprehvir therapy.

The design constraints for the tooth pro le of the ve-arc R oots vacuum pump are derived and discussed in this paper. The addendum portion of the ve-arc tooth pro le comprises ve smoothly connected circular arcs, while the dedendum portion consists of conjugate curves of the addendum portion of the mating rotor. The top land of the proposed rotor pro le is a circular arc with its centre coinciding with the centre of rotation. Therefore, the gap between the top land of the rotor and the wall of the chamber turns into a long and narrow path, which provides better gas sealing and wider inlet opening. The design constraints of the rotor pro le are quite complex owing to the limitations of zero carryover and the condition of non-undercutting. A design procedure is proposed for determining the feasible design region by considering the geometry constraints, zero carryover and non-undercutting. By using the proposed procedure, wider inlet opening and better gas sealing are expected, while the characteristic of zero carryover is maintained. The results of experiment show that the ultimate pressure of the prototype of the ve-arc R oots vacuum pump is 2 5610 ¡3 torr, and the maximum pumping speed is 1600 L/min. The performance of the prototype is excellent compared with commercially available mechanical dry vacuum pumps.