To assess the prognostic impact of short-term blood pressure variability among heart failure patients with reduced ejection fraction.
Methods:The pooled endpoint of cardiac death, stroke, myocardial infarction, and hospitalization were examined in 156 HF subjects with reduced EF. All subjects had their blood pressure measured ambulatorily. Mean average real variability (ARV) 24-hour systolic BP (n=78; n=78) was used to classify individuals as having the lowest (0.77 mmHg) or the highest (0.77 mmHg) ARV.
Results:Throughout the follow-up period (7.6 ± 3.6 months), 107 events occurred, of which 29 (19%) were cardiac deaths, 18 (12%) myocardial infarction, 9 (6%) stroke, and 51(33%) hospitalizations. Patients with low 24-hour systolic ARV had significantly higher cardiac death and MI than those with high 24-hour systolic ARV. Risk of negative outcomes identified as an independent variable by logistic regression analysis; age (AOR 1.
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