Ensuring travellers' health and well-being is an important issue in tourism management and public health. By applying and testing the Protection Motivation Theory (PMT), this study serves as one of the early attempts in tourism to explore travellers' self-protective behavior against health risks. This study conducted semi-structured interviews and an online survey.Consistent with the PMT, this study found that both threat and coping appraisals can enhance travellers' protection motivations, which in turn affect their actual behaviors. Intentions play a mediation role between appraisals and actual behavior. Notably, maladaptive perception was adapted to fit tourism and was found negatively associated with the coping appraisal. This study also provides implications on how to encourage travellers to protect themselves against health risks.

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From the perspective of transactive energy, the energy trading among interconnected microgrids (MGs) is promising to improve the economy and reliability of system operations. In this paper, a distributed energy management method for interconnected operations of combined heat and power (CHP)-based MGs with demand response (DR) is proposed. First, the system model of operational cost including CHP, DR, renewable distributed sources, and diesel generation is introduced, where the DR is modeled as a virtual generation unit. Second, the optimal scheduling model is decentralized as several distributed scheduling models in accordance with the number of associated MGs. Moreover, a distributed iterative algorithm based on subgradient with dynamic search direction is proposed. During the iterative process, the information exchange between neighboring MGs is limited to Lagrange multipliers and expected purchasing energy. Finally, numerical results are given for an interconnected MGs system consisting of three MGs, and the effectiveness of the proposed method is verified.

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality and no proven therapy. Here, we reported a severe uremic calciphylaxis patient with progressive skin ischemia, large areas of painful malodorous ulcers, and mummified legs. Because of the worsening symptoms and signs refractory to conventional therapies, treatment with human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Pre-clinical release inspections of hAMSCs, efficacy, and safety assessment including cytokine secretory ability, immunocompetence, tumorigenicity, and genetics analysis in vitro were introduced. We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats, abnormal immune response tests in C57BL/6 mice, and tumorigenicity tests in neonatal Balbc-nu nude mice. After the pre-clinical research, the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers. When followed up to 15 months, the blood-based markers of bone and mineral metabolism improved, with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells. Skin biopsy after 1-month treatment showed vascular regeneration with mature non-calcified vessels within the dermis, and 20 months later, the re-epithelialization restored the integrity of the damaged site. No infusion or local treatment-related adverse events occurred. Thus, this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis with effects of inhibiting vascular calcification, stimulating angiogenesis and myogenesis, anti-inflammatory and immune modulation, multi-differentiation, re-epithelialization, and restoration of integrity.

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Since the consumption of non‐renewable sources is diminishing day‐by‐day, most of the developing countries across the globe are facing a severe energy crisis. This energy crisis affects the developing countries such as Pakistan so extensively that population has a crucial problem of load shedding for long hours. Thus, there exists a fundamental need for alternative and economical energy resources, for example, solar, wind, and biofuel energy. Meanwhile, out of all the financially viable ways of power generation, the wind energy is considered as the most economical way. However, in this article authors selected six potential wind zones which lie within 1100 km of coastal zones. In this study, only 1‐year wind speed raw data is considered and taken from appropriate wind zones at various heights with the support of Pakistan Metrological Department. Besides all, this project encourages the domestic as well as the foreign investor to invest in the wind energy projects at windy zones, which basically opens the business doors for the community of Pakistan for power generation, which leads to overcoming the energy crisis along the countryside. © 2018 American Institute of Chemical Engineers Environ Prog, 38: 706–720, 2019

Background: Non-suicidal self-injury (NSSI) behavior among college students is a focus of attention in current society. In the information era, the Internet serves as a public health concern and as an effective pathway for prevention. In order to reduce NSSI behavior, we explore its influence factors, especially the relations between neuroticism, emotion regulation (ER), depression, and NSSI behavior. Methods: A total of 450 college students were surveyed with the Big Five Inventory-2, Emotion Regulation Questionnaire, Self-Rating Depression Scale, and Adolescent Non-Suicidal Self-Injury Assessment Questionnaire. Results: Regression analysis showed that neuroticism significantly negatively predicted emotion regulation, while it positively predicted depression and NSSI. Multiple mediation modeling demonstrated that neuroticism and emotion regulation had no significant direct effects on NSSI. However, neuroticism could indirectly affect NSSI through four pathways of multiple mediating effects, including depression, cognitive reappraisal-depression, expressive suppression-depression, and cognitive reappraisal-expressive suppression-depression. Conclusions: Neuroticism positively predicts depression and NSSI behavior, and affects NSSI through the mediating effect of ER and depression. Therefore, amelioration of neuroticism from the perspectives of emotion regulation and depression is recommended, so as to reduce NSSI behavior among college students with highly neurotic personalities.

Schistosomiasis is a common zoonoses affecting humans. The atypical clinical symptoms, low morbidity, and low degree of infection impede diagnosis and assessment of epidemics. Detecting circulating antigens from adult worms in patients' body fluids should be diagnostically superior to examining eggs in feces. Herein, the excretory-secretory proteins of adult worms were analyzed by using 2-D protein electrophoresis and mass spectrometry. The Schistosoma japonicum enolase (Sj enolase) was identified as the most abundant excretory-secretory antigen. Purified recombinant Sj enolase was prepared, and specific monoclonal and polyclonal antibodies were raised against it. A sandwich enzymelinked immunoassay (sandwich ELISA) was established that used the monoclonal antibody as a capture antibody and the polyclonal antibody as a detection antibody. The linear detection range was 0.7-1000 ng/ml (minimum 700 pg/ml). Sj enolase could be detected in the sera of infected rabbits and disappeared rapidly postpraziquantel treatment. The sensitivity and specificity of this sandwich ELISA to detect field serum samples of schistosomiasis were 84.61 and 95.83 %, respectively. The cross-reaction rates for clonorchiasis and paragonimiasis were 3.33 and 5 %, respectively. This ELISA assay was used to test 45 matching sera of schistosomiasis patients before treatment and at 3, 6, 9, and 12 months posttreatment. Among the sera, 88.89 % were positive before treatment. At 3, 6, 9, and 12 months postpraziquantel treatment, 93.33, 97.78, 100, and 100 % tested negative, respectively. Therefore, Sj enolase can be used to indicate active Schistosoma infection, and detecting serum Sj enolase is important for diagnosis and evaluating treatment effect.