To evaluate the prognostic value of numbers of negative lymph nodes (NLNs) for patients with perihilar cholangiocarcinomas.
The surveillance, epidemiology, and end results database was used to screen for patients with perihilar cholangiocarcinomas. Kaplan–Meier and Cox regression analyses were used for statistical evaluations. Subsequently, propensity score matching (PSM) was performed to confirm the results.
A total of 938 patients with perihilar cholangiocarcinomas met the inclusion criteria. The cut-off number for the grouping of patients with different numbers of NLNs was 17. Both the univariate and multivariate survival analyses demonstrated that there was a significant improvement in terms of cancer-specific survival for patients with >17 NLNs, compared with patients with ≤17 NLNs. Then, the above results were confirmed via a PSM procedure. Additionally, the independent prognostic value of NLNs was evaluated in subgroup univariate and multivariate analyses of patients with stage I or stage II tumors.
The numbers of NLNs were evaluated and determined to be important independent prognostic factors for the cancer-specific survival of patients with perihilar cholangiocarcinomas.
Objective
To compare 1‐ and 2‐day drug administration interval between mifepristone and misoprostol for second‐trimester pregnancy termination and provide evidence‐based recommendations.
Methods
Search strategy: the search was performed in Pubmed, EMBASE, and Cochrane Library for the relevant published studies from their establishment to March 2020. Selection criteria: randomized controlled trials (RCTs) comparing 1‐ and 2‐day time interval of mifepristone‐misoprostol for termination of pregnancy during second‐trimester pregnancy were considered. Data were processed using Revman 5.3 software.
Results
Meta‐analyses of three RCTs showed no significant difference was reported in the induction‐to‐abortion time and successful abortion rate between 1‐ and 2‐day mifepristone and misoprostol intervals. Statistical difference was not identified in the induction‐to‐abortion time between the two drug administration intervals in nulliparous or parous women.
Conclusions
Both 1‐ and 2‐day dosing intervals between mifepristone and misoprostol are suitable for clinical use for second‐trimester medical termination of pregnancy.
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